Background: Limited data on the impacts of oral anti-diabetic drugs (OADs) on patient vital functions are available. This study assessed the differential effects of OADs on glycemic control and hepatic and renal function in type 2 diabetes mellitus (T2DM) patients in Cameroon.
Methods: This cross-sectional study was done on 125 T2DM patients from Nkwen District Hospital, Bamenda (Cameroon). The patients’ socio-demographic characteristics and OADs were collected, while glycated hemoglobin (HbA...
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Ethanolic leaf extract of Crinum distichum reverses carbon tetrachloride-induced hepatic fibrosis in rats
Abstract
Background: Liver diseases are increasingly recognized as significant public health issues, with cirrhosis alone ranking 12th as the leading cause of death worldwide. This study aimed to evaluate the anti-fibrotic effects of ethanolic leaf extract of Crinum distichum (CDE) in male Wistar rats with Carbon tetrachloride (CCl4)-induced liver fibrosis.
Methods: Phytochemical profiling of CDE was assessed through High Performance Liquid Chromatography/Mass spectrometry (HPLC/MS) analy...
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Anti-inflammatory, analgesic, and antipyretic activities of aqueous and methanol stem bark extracts of Drypetes gossweileri in persistent inflammatory pain induced by complete Freund’s adjuvant in rats
Abstract
Background: Drypetes gossweileri (Euphorbiaceae) is a medicinal plant used in Cameroon to treat toothache, gastritis, and pain. This study was conducted to evaluate the anti-inflammatory, analgesic, and anti-pyretic effects of the aqueous (AEDG) and methanol (MEDG) stem bark extracts in a persistent inflammatory pain model induced by Complete Freund’s Adjuvant (CFA) in rats.
Methods: Inflammatory pain was induced by intra-plantar injection of 50 µL of CFA into the left hind paw o...
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Antibacterial activity and antibiotic-potentiating effects of Termnalia laxiflora and Azadirachta indica against multidrug-resistant Staphylococcus aureus
Abstract
Background: S. aureus is a multidrug-resistant (MDR) bacterium that poses a significant public health threat globally. In response, plants have emerged as promising alternatives in combatting infections caused by this pathogen. This study aims to evaluate the efficacy of two medicinal plants against MDR Gram-positive Staphylococcus aureus.
Methods: The antibacterial activity of various plant extracts was assessed both individually and in combination with conventional antibiotics ...
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Antidiabetic effects of Cassia abbreviata Oliv. leaf fractions extracts in type 2 diabetic male adult Wistar rats
Abstract
Background: Globally, type 2 diabetes mellitus, or diabetes, comprises over 96% of all diabetic cases. Therefore, we investigated the antidiabetic effects of Cassia abbreviata fractions of chloroform, ethyl acetate, and petroleum ether in type 2 diabetic male adult Wistar rats.
Methods: Type 2 diabetes was induced via a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) following a high-fat, high-sucrose diet. Diabetic rats were treated with different fract...
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Inhibitors of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase: In-silico evaluation of phenylpiperazinyl derivatives
Abstract
Background: Resistance to existing antifolate drugs targeting the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is a major obstacle to malaria control. Furthermore, some current drugs have associated toxicity concerns. To address this, we explored new antifolate inhibitors to develop safer and more potent antimalarial drugs.
Methods: We computationally screened hypothetical compounds A1, A2, and A3 (a parent compound and two alcohol derivatives) for their toxicit...
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Soursop (Annona muricata L.) seed extracts: phytochemical composition and biocontrol potential against cercosporiosis in okra (Abelmoschus esculentus L. Moech)
Abstract
Background: Annona muricata, or soursop, is a tropical plant known for antimicrobial and antiparasitic properties, widely used in traditional remedies. Extracts from leaves, seeds, and bark show activity against pathogens in humans and plants, making it a promising candidate for natural biopesticide development as safer alternatives to chemical controls. This study evaluates Annona muricata seed extracts as bio-fungicides against Cercospora leaf spot in okra under field conditions.
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Seroprevalence of hepatitis C among blood donors at the National Blood Transfusion Center (NBTC) of N’Djamena in 2022: a cross-sectional and analytical study
Abstract
Background: In Africa, hospital blood demand is important; but inadequately managed and hence hazardous. So far, only a few studies in Chad have reported hepatitis C among blood donors and examined its influence on their clinical state. The goal of our study was to assess hepatitis C seroprevalence among blood donors at the National Blood Transfusion Center (NBTC) in Ndjamena, identify risk factors, and analyze the biochemical profile.
Methods: A descriptive and cross-sectional s...
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In-silico study of aminobenzoic acid Schiff base copper-complexes as potential cell inhibitors of cyclin-dependent kinase 7
Abstract
Background: Cell inhibitors are gradually becoming a tool in drug discovery as this gives a lead to potential compounds with therapeutic application. Presently, cancer cell inhibitors have shown drug-likeness based on oral bioavailability, pharmacokinetics, global chemical reactivity and theoretical binding affinities. Herein, we report copper complexes synthesized from aminobenzoic acid moiety, 3-(2-hydroxybenzylideneamino) benzoic acid copper complex and 4-(2-hydroxybenzylideneami...
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Pharmacological impact of secondary metabolites of Senecio biafrae vegetable for PPARα agonist, antioxidant, hepatoprotection, hematological, histopathological and antimicrobial potential
Abstract
Background: This study was aimed at investigating the in-silico and in-vivo hepatoprotective, antioxidant, and antimicrobial potential of Senecio biafrae (Olive and Hierne) C. Jeffrey (Asteraceae).
Methods: The chemoinformatic assay was conducted using ligands against hepatic peroxisome proliferator-activated receptor binding protein (PPARα). Lipid examination, liver function tests, antioxidant, hematological, and histopathological examinations were studied to evaluate the hepato...
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