Abstract
Background: Globally, type 2 diabetes mellitus, or diabetes, comprises over 96% of all diabetic cases. Therefore, we investigated the antidiabetic effects of Cassia abbreviata fractions of chloroform, ethyl acetate, and petroleum ether in type 2 diabetic male adult Wistar rats.
Methods: Type 2 diabetes was induced via a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) following a high-fat, high-sucrose diet. Diabetic rats were treated with different fract...
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Inhibitors of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase: In-silico evaluation of phenylpiperazinyl derivatives
Abstract
Background: Resistance to existing antifolate drugs targeting the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is a major obstacle to malaria control. Furthermore, some current drugs have associated toxicity concerns. To address this, we explored new antifolate inhibitors to develop safer and more potent antimalarial drugs.
Methods: We computationally screened hypothetical compounds A1, A2, and A3 (a parent compound and two alcohol derivatives) for their toxicit...
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Soursop (Annona muricata L.) seed extracts: phytochemical composition and biocontrol potential against cercosporiosis in okra (Abelmoschus esculentus L. Moech)
Abstract
Background: Annona muricata, or soursop, is a tropical plant known for antimicrobial and antiparasitic properties, widely used in traditional remedies. Extracts from leaves, seeds, and bark show activity against pathogens in humans and plants, making it a promising candidate for natural biopesticide development as safer alternatives to chemical controls. This study evaluates Annona muricata seed extracts as bio-fungicides against Cercospora leaf spot in okra under field conditions.
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Seroprevalence of hepatitis C among blood donors at the National Blood Transfusion Center (NBTC) of N’Djamena in 2022: a cross-sectional and analytical study
Abstract
Background: In Africa, hospital blood demand is important; but inadequately managed and hence hazardous. So far, only a few studies in Chad have reported hepatitis C among blood donors and examined its influence on their clinical state. The goal of our study was to assess hepatitis C seroprevalence among blood donors at the National Blood Transfusion Center (NBTC) in Ndjamena, identify risk factors, and analyze the biochemical profile.
Methods: A descriptive and cross-sectional s...
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In-silico study of aminobenzoic acid Schiff base copper-complexes as potential cell inhibitors of cyclin-dependent kinase 7
Abstract
Background: Cell inhibitors are gradually becoming a tool in drug discovery as this gives a lead to potential compounds with therapeutic application. Presently, cancer cell inhibitors have shown drug-likeness based on oral bioavailability, pharmacokinetics, global chemical reactivity and theoretical binding affinities. Herein, we report copper complexes synthesized from aminobenzoic acid moiety, 3-(2-hydroxybenzylideneamino) benzoic acid copper complex and 4-(2-hydroxybenzylideneami...
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Pharmacological impact of secondary metabolites of Senecio biafrae vegetable for PPARα agonist, antioxidant, hepatoprotection, hematological, histopathological and antimicrobial potential
Abstract
Background: This study was aimed at investigating the in-silico and in-vivo hepatoprotective, antioxidant, and antimicrobial potential of Senecio biafrae (Olive and Hierne) C. Jeffrey (Asteraceae).
Methods: The chemoinformatic assay was conducted using ligands against hepatic peroxisome proliferator-activated receptor binding protein (PPARα). Lipid examination, liver function tests, antioxidant, hematological, and histopathological examinations were studied to evaluate the hepato...
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Antioxidant and antidiabetic properties, and safety profile of methanolic extract of Garcinia kola seed (bitter kola)
Abstract
Background: Diabetes mellitus is growing global health concerns and conventional treatments for diabetes present limitations, prompting exploration of alternative therapeutic approaches. Garcinia kola seed from the family Clusiaceae is known for its medicinal properties and it is used as a traditional medicine for antidiabetic management. This study aimed to investigate the phytochemicals, antioxidant and antidiabetic activities as well as safety profile of the methanolic extract of...
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A combination of Psidium guajava and Aloe vera Aqueous Extracts Prevents Ethanol-Induced Gastric Ulcer in Rats through Suppression of Oxidative Stress and Gastric Inflammation
Abstract
Background: Gastric ulcers are a common gastrointestinal disorder for which there is a need to search for a better prevention method or treatment options. Accordingly, this study aimed to assess the protective effect of a combination of Psidium guajava and Aloe vera extracts against ethanol-induced gastric ulcers in rats.
Methods: The gastric ulcer was induced in rats using one oral dose of absolute ethanol (5 mL/kg body weight (b.w)). A combination of P. guajava and A. vera at d...
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Pericopsis laxiflora (Baker) Stem bark extract ameliorates acute Lead-induced hepatotoxicity: Modulation of Oxidative Stress and Inflammatory Pathways
Abstract
Background: Heavy metals such as lead are considered a toxicant that can cause multiple organ complications including cancer, liver disease, renal diseases, neurodegenerative diseases, and reproductive diseases. In pursuit of a low-cost and easily accessible antidote, this research examined the role of Pericopsis laxiflora extract in acute lead poisoning in Sprague-Dawley rats.
Methods: Liver damage was caused in animal studies by inducing lead acetate (50 mg/kg daily, intraperit...
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Botanicals from the flowers of Vernonia calvoana and the leaves of Senna spectabilis showed anti-Klebsiella activity and potentiated the activity of antibiotics against multidrug-resistant phenotypes overexpressing efflux pumps
Abstract
Background: The alarming trend of infectious diseases in public health is mainly due to bacterial multidrug resistance, the emergence of which is partly caused by the inappropriate use of antibiotics. Bacteria of the Klebsiella genus have acquired a priority level of resistance to antibiotics, reducing their effectiveness. The aim of this study was to evaluate the anti-Klebsiella activity of methanol extracts of Vernonia calvoana flowers and Senna spectabilis leaves against multidru...
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