Antiproliferative properties of labdane diterpenoids from Croton sylvaticus Hochst against drug sensitive and resistant leukemia cell lines

Abstract  Background: Cancer treatment failure is majorly attributed to the emergency of multi-drug resistance of cancer cells towards most conventional drugs used in chemotherapy hence the need for more active principles with less side effective from natural sources. Methods: Characterization of isolated compounds was achieved using NMR spectroscopy and comparison of acquired data with literature values. The antiproliferative properties were determined using resazurin reduction assay. ...
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