Anthelmintic resistance modifying properties of extracts of Cyperus difformis L. (Cyperiaceae)

-Francis Adu; Christian Agyare; George Henry Sam; Yaw Duah Boakye; Vivian Etsiapa Boamah.

Francis Adu1, Christian Agyare1*, George Henry Sam2, Yaw Duah Boakye1, Vivian Etsiapa Boamah1 Investigational Medicinal Chemistry and Pharmacology 2018 1(1):3 Abstract Background: Resistance by parasites to anthelmintic drugs is known to be on the increase and little attention is paid to the subject. The aim of study was to determine the anthelmintic and helminth resistance modifying activities of methanol whole plant Cyperus difformis extract against the adult Indian worm Pherethima p...

Catechin Derivatives from Parkia biglobosa Displayed Selective Cytotoxicity Towards Leukemia CCRF-CEM Cell Line and its P-Glycoprotein Expressing Subline CEM/ADR5000

-Victor Kuete; Viviane R. Sipowo Tala; Armelle T. Mbaveng; Viviane Cândida da Silva; Clenilson M. Rodrigues; Augustin E. Nkengfack; Lourdes Campaner dos Santos; Wagner Vilegas; Thomas Efferth.

Investigational Medicinal Chemistry and Pharmacology 2018; 1(1):2 Abstract Background: Cancer chemotherapy is challenged by drug resistance of malignant cells. In the present work, we evaluated the cytotoxicity of four catechin derivatives, 4’-methylepigallocatechin (1), gallocatechin (2), epigallocatechin (3), epigallocatechin-3-O-gallate (4) against nine drug sensitive and multidrug resistant (MDR) cancer cell lines. Methods: The resazurin reduction assay was used to evaluate the cyt...