Abstract Background: The global burden of bacterial infections remains a serious health concern. In the present review, we have summarized the best botanicals and phytochemicals from the flora of Africa that deserve clinical studies to develop novel antibacterial drugs to combat enterobacteria, Pseudomonas aeruginosa, Gram-positive bacteria, and mycobacteria. Methods: Data were retrieved from scientific databases such as PubMed, Scopus, ScienceDirect, Google Scholar, and Web of Science us...