In-silico study of aminobenzoic acid Schiff base copper-complexes as potential cell inhibitors of cyclin-dependent kinase 7

-Felicia Ndidi Ejiah; Oluwafemi Segun Aina; Inemesit Asukwo Udofia; Tolulope Mojisola Fasina; and Oluwole Babafemi Familoni.

Abstract Background: Cell inhibitors are gradually becoming a tool in drug discovery as this gives a lead to potential compounds with therapeutic application. Presently, cancer cell inhibitors have shown drug-likeness based on oral bioavailability, pharmacokinetics, global chemical reactivity and theoretical binding affinities. Herein, we report copper complexes synthesized from aminobenzoic acid moiety, 3-(2-hydroxybenzylideneamino) benzoic acid copper complex and 4-(2-hydroxybenzylideneami...

Pharmacological impact of secondary metaboiltes of Senecio biafrae vegetable for PPARα agonist, antioxidant, hepatoprotection, hematological, histopathological and antimicrobial potential

-Zacchaeus S. Ololade; Mariam T. Akorede-Oloye; Christianah A. Akinawo; Jumoke R. Adekunbi; Adewumi I. Adeagbo; Olayinka F. Onifade; Olawumi T. Oyebanji; and Anikeola C. Olaniran.

Abstract Background: This study was aimed at investigating the in-silico and in-vivo hepatoprotective, antioxidant, and antimicrobial potential of Senecio biafrae (Olive and Hierne) C. Jeffrey (Asteraceae). Methods: The chemoinformatic assay was conducted using ligands against hepatic peroxisome proliferator-activated receptor binding protein (PPARα). Lipid profile, liver function tests, antioxidant, hematological, and histopathological profiles were studied to evaluate the hepatoprotecti...

Antioxidant and antidiabetic properties, and safety profile of methanolic extract of Garcinia kola seed (bitter kola)

-Nestor Tordzagla; Emmanuel Eddie Blay; Baba Sulemana Mohammed.

Abstract Background: Diabetes mellitus is growing global health concerns and conventional treatments for diabetes present limitations, prompting exploration of alternative therapeutic approaches. Garcinia kola seed from the family Clusiaceae is known for its medicinal properties and it is used as a traditional medicine for antidiabetic management. This study aimed to investigate the phytochemicals, antioxidant and antidiabetic activities as well as safety profile of the methanolic extract of...

A combination of Psidium guajava and Aloe vera Aqueous Extracts Prevents Ethanol-Induced Gastric Ulcer in Rats through Suppression of Oxidative Stress and Gastric Inflammation

-Thiery Tania Meseme; Tanayen Julius Kihdze; Francis Desiré Tatsinkou Bomba; Eleonore Ngounou; Arnaud Fondjo Kouam; Asongalem Emmanuel Acha.

Abstract Background: Gastric ulcers are a common gastrointestinal disorder for which there is a need to search for a better prevention method or treatment options. Accordingly, this study aimed to assess the protective effect of a combination of Psidium guajava and Aloe vera extracts against ethanol-induced gastric ulcers in rats. Methods: The gastric ulcer was induced in rats using one oral dose of absolute ethanol (5 mL/kg body weight (b.w)). A combination of P. guajava and A. vera at d...