Ethanolic leaf extract of Crinum distichum reverses carbon tetrachloride-induced hepatic fibrosis in rats

-Melanie Numbu; Arnaud Kouam Fondjo; Eleonore Ngounou; Elisabeth Menkem Zeuko’o; Branly-natalien Nguena-dongue; Napoleon Mfonku; and Gregory Edie Halle-Ekane

Abstract Background: Liver diseases are increasingly recognized as significant public health issues, with cirrhosis alone ranking 12th as the leading cause of death worldwide. This study aimed to evaluate the anti-fibrotic effects of ethanolic leaf extract of Crinum distichum (CDE) in male Wistar rats with Carbon tetrachloride (CCl4)-induced liver fibrosis. Methods: Phytochemical profiling of CDE was assessed through High Performance Liquid Chromatography/Mass spectrometry (HPLC/MS) analy...

Anti-inflammatory, analgesic, and antipyretic activities of aqueous and methanol stem bark extracts of Drypetes gossweileri in persistent inflammatory pain induced by complete Freund’s adjuvant in rats

-Francis Desire Tatsinkou Bomba; Uzuegbu Esther Nyechukwu; Bibiane Aimee Wandji; Erastus Nembu Nembo; Armel Jackson Seukep; Arnaud Fodjo Kouam; Marius Mbiantcha; Telesphore Benoit Nguelefack; and Emmanuel Acha Asongalem.

Abstract Background: Drypetes gossweileri (Euphorbiaceae) is a medicinal plant used in Cameroon to treat toothache, gastritis, and pain. This study was conducted to evaluate the anti-inflammatory, analgesic, and anti-pyretic effects of the aqueous (AEDG) and methanol (MEDG) stem bark extracts in a persistent inflammatory pain model induced by Complete Freund’s Adjuvant (CFA) in rats. Methods: Inflammatory pain was induced by intra-plantar injection of 50 µL of CFA into the left hind paw o...

Antibacterial activity and antibiotic-potentiating effects of Termnalia laxiflora and Azadirachta indica against multidrug-resistant Staphylococcus aureus

-Larissa Mpude; Eric Cadet; Derick J. Assonfack; Ancela W. B. Yendze; Jenifer R. N. Kuete; Valaire Y. Matieta; Junior F. Megaptche; Michael F. Kengne; Idrios N. Bonsou; Armelle T. Mbaveng; and Victor Kuete.

Abstract Background: S. aureus is a multidrug-resistant (MDR) bacterium that poses a significant public health threat globally. In response, plants have emerged as promising alternatives in combatting infections caused by this pathogen. This study aims to evaluate the efficacy of two medicinal plants against MDR Gram-positive Staphylococcus aureus. Methods: The antibacterial activity of various plant extracts was assessed both individually and in combination with conventional antibiotics ...