Investigation of insulin resistance and glycemic response to Dennettia tripetala essential oil in steptozocin-induced diabetic mice

-Tajudin Adesegun Adetunji; Abiodun Kofoworola Ajeigbe; Ummulkhair Funke Adetunji; and Idris Ajayi Oyemitan.

Abstract Background: The growing influence of medicinal plants among individuals living with diabetes in developing nations is a major concern for safety, efficacy, and tolerability. This study investigated the median lethal dose (LD50), antihyperglycemic effects, and potential mechanisms of action of the essential oil (EO) from the dried seeds of Dennettia tripetala (D. tripetala) in streptozocin (STZ)-induced diabetic mice. Methods: The EO was obtained by hydrodistillation of pulverized...

Acute toxicity evaluation of Opuntia stricta Cladode grown in Zambia on Wistar albino rodents

-Martin Kampamba; Christian Chinyere Ezeala; Kadango Zombe; and Angela Gono Bwalya.

Abstract Background: Traditionally, Opuntia stricta has been used to manage diabetes mellitus in many parts of the world, including Zambia. However, while a few studies elsewhere have assessed the safety of Opuntia stricta, no study to date has established its safety in Zambia. The study aimed to evaluate the acute toxicity of Opuntia Stricta cladode (OSC) on Wistar albino rodents. Methods: At dosages of 0.5 g/kg, 1 g/kg, and 2 g/kg per os (p.o), an acute oral toxicity test was conducted ...

In vitro antiplasmodial, anthelmintic activities and toxicological profile of the leaves, roots, and stem bark of Ficus bubu Warb

-Eugène Ekounè Kamè; Edwige Laure Nguemfo; Sandrine Evelyne Nsango; Lawrence Ayong; Else Carole Eboumbou Moukoko; Giselle Marie Marguerite Etamè Loe; and Jean Emmanuel Mbosso Teinkela.

Abstract Background: Ficus bubu is a fig tree belonging to the Moraceae family, whose leaves, roots, and stem bark contain bioactive compounds identified through qualitative and quantitative phytochemical screening. While these parts are known for their antioxidant activities, scientific data on their antiplasmodial and anthelmintic activities, as well as toxicological profiles, have not yet been reported. Methods: Acute toxicity testing was performed on all three plant parts. Additionall...

Comparative effects of oral antidiabetic regimens, exercise and BMI on glycemic control and organ function in type 2 diabetes mellitus patients in Bamenda, Cameroon

-Junior Tegha Kum Muankang; Andre Gilles Mache; Aphrodite Choumessi Tchewonpi; Olivia Maih Tim; Christian Fusi Suh; Faustin Pascal Tsague Manfo; Promise Penn Muluh; and Edouard Nantia Akono

Background: Limited data on the impacts of oral anti-diabetic drugs (OADs) on patient vital functions are available. This study assessed the differential effects of OADs on glycemic control and hepatic and renal function in type 2 diabetes mellitus (T2DM) patients in Cameroon. Methods: This cross-sectional study was done on 125 T2DM patients from Nkwen District Hospital, Bamenda (Cameroon). The patients’ socio-demographic characteristics and OADs were collected, while glycated hemoglobin (HbA...