Targeting larvae and odorant-binding proteins for mosquito control: Experimental and in-silico investigations of Schiff bases containing aminophenol moiety

-Felicia Ndidi Ejiah; Fouad Abidemi Adetoro; Oluwabusola Folake Lawal; Mujeeb Olarewaju Rofiu.

Abstract Background: Controlling mosquitoes is crucial for public health globally. Presently, the emphasis is on transitioning from conventional insecticides to viable alternatives such as larvicide options. This study aims to determine the effectiveness of two Schiff base compounds as larvicides and repellents for mosquito control. Methods: The stock solution of two Schiff base compounds (Z)-2-((2-hydroxybenzylidene)amino)phenol (MO) and (Z)-4-bromo-2-(((2-hydroxyphenyl)imino)methyl)-phe...

Combining extracts of Zingiber officinale rhizomes and dried fruits of Tetrapleura tetraptera improve oxidative stress and hematological profiles, reduces joint inflammation and hyperalgesia after carrageenan injection in rat joints

-Marcelle Djami Bejoutance; Danielle Claude Bilanda: William Yousseu Nana; Francis Desire Bomba Tatsinkou; Albert Donatien Atsamo; Stéphanie Flore Djuichou Nguemnang; Marcelle Olga Feigni Youyou; Jovanie Destin Bakouatche; Miariam Flore Kana; Marius Mbiantcha; Gilbert Ateufack; Paul Desiré Dzeufiet Djomeni.

Abstract Background: Zingiber officinale and Tetrapleura tetraptera are recognized and widely used for medicinal and nutritional qualities. The study aimed to evaluate the anti-inflammatory properties of the mixture of the aqueous and ethanolic extracts of Zingiber officinale and Tetrapleura tetraptera. Methods: Joint inflammation induced by carrageenan (3%), the clinical signs of inflammation (paw edema) and pain (mechanical hyperalgesia and tactile allodynia), biochemical, hematological...

Allium cepa bulbs (Alliaceae) and Syzygium aromaticum spices (Myrtaceae) aqueous extracts mixture protects the knee joint and the features associated with movement in a model of locomotor dysfunction induced by the monoidoacetate on Wistar rat

-Jovanie Destin Bakouatche; Marcelle Bejoutance Djami; Desire Francis Tatsinkou Bomba;Ernest Allah Hoki Kwenthe; William Nana Yousseu; Donatien Albert Atsamo; Carlos Yannick Tcheutchoua; Flore Miariam Kana; Marius Mbiantcha; Gilbert Ateufack; and Bertrand Alain Dongmo.

Abstract Background: Allium cepa (Onion) is widely used as a flavored vegetable in various types of foods and against urinary system disorders, ear disorders, and injuries. Syzygium Aromaticum (clove) is used as a local anesthetic, also used against pain, rheumatological, and antioxidant problems. This study aimed to show the protective effects of the aqueous extract of the mixture of Onion and clove in the occurrence of a joint pathology such as osteoarthrosis. Methods: The animals were ...

Callistemon citrinus essential oil from Cameroon: potent inhibitor of bacterial respiratory pathogens without inducing resistance or persistence

-Marc Flaubert Yumsu Tcham; Ebenezer Tatiekam Foka; Cedric Fossi Tchinda; Armelle Deutou Tchamgoue; Véronique Beng Penlap; and Jean Paul Assam Assam

Abstract Background: Antibiotic resistance, persistent cells in respiratory infections, and adverse effects associated with antibiotics underscore the urgent need to search for alternative treatments. Natural products such as essential oils derived from aromatic plants like Callistemon citrinus may be a promising avenue to explore. This study aimed to assess the antibacterial activity of C. citrinus essential oils from two Cameroonian regions against bacteria causing respiratory infections, ...

Translational preclinical evaluation of Strychnos innocua leaf extract: Investigating anti-nociceptive and antidepressant activities using in vivo and in silico models

-Chinedu Enegide; Eugene Ehimare; Divine Odeworitse; Ujunwa Emelda Ezeanochie; Israel Ofejiro Efejene; Michael Eromosele Aisuodionoe; Osasengo Precious Osifo; Esther Adaeze Ossai; Emmanuella Chukwufumnanya Nwegbu; Sophia Onyinyechi Agundu; and Jennifer Orevaoghene Etiku.

Abstract Background: Pain represents a complex physiological response of tissues to injury and often adversely impacts both health and quality of life. Epidemiological data indicate that virtually all individuals will experience some form of pain during their lifetime. Strychnos innocua (family Loganiaceae) is employed in ethnomedicine for the treatment of inflammation, pain, central nervous system disorders, and various other ailments. This study investigated the antinociceptive and antide...