Pharmacological and molecular insights into β-glucan-rich Saccharomyces cerevisiae var. boulardii: In vivo and in silico protection against arsenic-induced redox and hematologic imbalance

-Moses Blessing Thomas; Muankang Junior Tegha Kum; Orhonigbe Innocent; Ozougwu Vincent; Ogara Amaechi; Ugwuene Francis; Agwu Linus, Uhuo Emmanuel; Achi Ngozi; Onoyima Samson; Onoja Remiguis; Ike Mmesoma; and Parker Elijah Joshua.

Abstract Background: Arsenic toxicity remains a major environmental and pharmacological concern in sub-Saharan Africa, with limited safe antidotes. Chronic exposure induces oxidative stress, hematologic dysfunction, and multi-organ injury through redox imbalance. Saccharomyces cerevisiae var. boulardii (SCb), a β-glucan-rich probiotic yeast, possesses antioxidant and immunomodulatory properties that may mitigate arsenic toxicity. This study combined in vivo and in silico approaches to elucid...

Cardioprotective effects of hydroalcoholic extract from Cinnamomum zeylanicum stem bark against isoproterenol-induced myocardial infarction in rats

-Albert Donatien Atsamo; Mireille Flaure Metchi Donfack; Gwladys Nyanga Nkomo; Marius Mbiantcha; Fidèle Ntchapda; and Théophile Dimo.

Abstract Background: The pharmacological properties of Cinnamomum zeylanicum have been predominantly explored in the context of cardiovascular diseases. Given its well-established anti-inflammatory and antioxidant properties, this study aimed to evaluate the cardioprotective potential of the hydroalcoholic extract of Cinnamomum zeylanicum barks (HECZ) against isoproterenol (ISO) induced cardiotoxicity. Methods: Rats were pre-treated with HECZ (200 - 400 mg/kg, p.o.) or 100 mg/kg of vitami...