Abstract
Background: Drypetes gossweileri (Euphorbiaceae) is a medicinal plant used in Cameroon to treat toothache, gastritis, and pain. This study was conducted to evaluate the anti-inflammatory, analgesic, and anti-pyretic effects of the aqueous (AEDG) and methanol (MEDG) stem bark extracts in a persistent inflammatory pain model induced by Complete Freund’s Adjuvant (CFA) in rats.
Methods: Inflammatory pain was induced by intra-plantar injection of 50 µL of CFA into the left hind paw of rats. AEDG and MEDG were given orally (100, 200, and 400 mg/kg) for 14 days after CFA administration. The anti-inflammatory, analgesic, and anti-pyretic effects were respectively measured using a digital caliper (paw edema), von Frey hair filaments (tactile allodynia), and a digital thermometer (fever). These parameters were recorded on 0, 1, 4, 7, 10, 13, and 14th days before and after CFA injection. On day 15, animals were sacrificed, brain and spinal cord collected for the measurement of oxidative stress parameters such as Nitric oxide (NO), superoxide dismutase (SOD), malondialdehyde (MDA), and catalase (CAT).
Results: Both AEDG and MEDG significantly (p<0.05, p<0.01, p<0.001) increased pain threshold, decreased paw edema and fever in animals along the treatment. NO and MDA were significantly (p<0.001) reduced in dose-dependent manner with MEDG in rats’ spinal cord. Furthermore, SOD and CAT activity were significantly and dose-dependently increased in both brain and spinal cord with AEDG and MEDG.
Conclusion: Our results demonstrated that AEDG and MEDG exhibit anti-inflammatory, antihypernociceptive, and anti-pyretic activities, which may be associated with their modulatory influence on oxidative stress markers.
Keywords: antihypernociceptive; anti-inflammatory; antipyretic effects; antioxidative stress; Drypetes gossweileri; stem barks
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