Abstract
Background: Cell inhibitors are gradually becoming a tool in drug discovery as this gives a lead to potential compounds with therapeutic application. Presently, cancer cell inhibitors have shown drug-likeness based on oral bioavailability, pharmacokinetics, global chemical reactivity and theoretical binding affinities. Herein, we report copper complexes synthesized from aminobenzoic acid moiety, 3-(2-hydroxybenzylideneamino) benzoic acid copper complex and 4-(2-hydroxybenzylideneami...
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Research article
Pharmacological impact of secondary metaboiltes of Senecio biafrae vegetable for PPARα agonist, antioxidant, hepatoprotection, hematological, histopathological and antimicrobial potential
Abstract
Background: This study was aimed at investigating the in-silico and in-vivo hepatoprotective, antioxidant, and antimicrobial potential of Senecio biafrae (Olive and Hierne) C. Jeffrey (Asteraceae).
Methods: The chemoinformatic assay was conducted using ligands against hepatic peroxisome proliferator-activated receptor binding protein (PPARα). Lipid profile, liver function tests, antioxidant, hematological, and histopathological profiles were studied to evaluate the hepatoprotecti...
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Antioxidant and antidiabetic properties, and safety profile of methanolic extract of Garcinia kola seed (bitter kola)
Abstract
Background: Diabetes mellitus is growing global health concerns and conventional treatments for diabetes present limitations, prompting exploration of alternative therapeutic approaches. Garcinia kola seed from the family Clusiaceae is known for its medicinal properties and it is used as a traditional medicine for antidiabetic management. This study aimed to investigate the phytochemicals, antioxidant and antidiabetic activities as well as safety profile of the methanolic extract of...
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A combination of Psidium guajava and Aloe vera Aqueous Extracts Prevents Ethanol-Induced Gastric Ulcer in Rats through Suppression of Oxidative Stress and Gastric Inflammation
Abstract
Background: Gastric ulcers are a common gastrointestinal disorder for which there is a need to search for a better prevention method or treatment options. Accordingly, this study aimed to assess the protective effect of a combination of Psidium guajava and Aloe vera extracts against ethanol-induced gastric ulcers in rats.
Methods: The gastric ulcer was induced in rats using one oral dose of absolute ethanol (5 mL/kg body weight (b.w)). A combination of P. guajava and A. vera at d...
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Pericopsis laxiflora (Baker) Stem bark extract ameliorates acute Lead-induced hepatotoxicity: Modulation of Oxidative Stress and Inflammatory Pathways
Abstract
Background: Heavy metals such as lead are considered a toxicant that can cause multiple organ complications including cancer, liver disease, renal diseases, neurodegenerative diseases, and reproductive diseases. In pursuit of a low-cost and easily accessible antidote, this research examined the role of Pericopsis laxiflora extract in acute lead poisoning in Sprague-Dawley rats.
Methods: Liver damage was caused in animal studies by inducing lead acetate (50 mg/kg daily, intraperit...
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Botanicals from the flowers of Vernonia calvoana and the leaves of Senna spectabilis showed anti-Klebsiella activity and potentiated the activity of antibiotics against multidrug-resistant phenotypes overexpressing efflux pumps
Abstract
Background: The alarming trend of infectious diseases in public health is mainly due to bacterial multidrug resistance, the emergence of which is partly caused by the inappropriate use of antibiotics. Bacteria of the Klebsiella genus have acquired a priority level of resistance to antibiotics, reducing their effectiveness. The aim of this study was to evaluate the anti-Klebsiella activity of methanol extracts of Vernonia calvoana flowers and Senna spectabilis leaves against multidru...
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Protective effect of hydroethanolic leaves extract of Solanum macrocarpon on Cisplatin-induced kidney injury in rats
Abstract
Background: Nephrotoxicity is a common kidney condition affecting many people worldwide, with conventional synthetic drugs not often yielding desirable results. This study, therefore, aimed to assess the protective effect of Solanum macrocarpon on Cisplatin-induced nephrotoxicity in Wistar rats.
Methods: Hydroethanolic extract of the leaves of S. macrocarpon was prepared and analyzed for basic phytochemical constituents. Cisplatin (5 mg/kg) was administered to induce nephrotoxici...
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Antibacterial and antibiotic-potentiation activities of methanol extracts from Blighia sapida K. D. Koenig (Sapindaceae) against Gram-negative multidrug-resistant bacteria overexpressing efflux pumps
Abstract
Background: The emergence and spread of multidrug-resistant (MDR) Gram-negative bacteria, particularly those overexpressing efflux pumps, make treatment difficult using conventional antibiotics. This study aims to assess the antibacterial activity of methanol extracts (botanicals) from the leaves (BSL) and bark (BSB) of Blighia sapida against a panel of MDR bacteria that overexpress efflux pumps.
Methods: Phytochemical screening of botanicals was carried out using standard qualit...
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Unveiling the anti-Klebsiella activity of methanol extracts from Hallea ciliata leaves and barks against multidrug-resistant strains overexpressing AcrAB-TolC efflux pumps
Abstract
Background: Infectious diseases are considered one of the most critical threats to public health. The present work aimed to determine the anti-Klebsiella activity of methanol extracts (botanicals) of Hallea ciliata leaves (HCL) and bark (HCB) against multidrug-resistant phenotypes over-expressing ACrAB-TolC efflux pumps.
Methods: The antibacterial activity of botanicals alone and in combination with PAβN and antibiotics, was determined using the broth microdilution method. The ef...
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Antibacterial activity and antibiotic-potentiating effects of methanol extracts from Ocimum basilicum and Sarcocephalus latifolius against multidrug-resistant Gram-negative bacteria overexpressing efflux pumps
Abstract
Background: The inappropriate use of antibiotics against bacterial infections leads to increased bacterial drug resistance. In the present study, the effectiveness of methanol extracts from the leaves and flowers of Ocimum basilicum and the roots of Sarcocephalus latifolius against multidrug-resistant (MDR) Gram-negative bacteria overexpressing efflux pumps was assessed.
Methods: The antibacterial properties of crude extracts (botanical, with and without phenylalanine arginine β-...
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