Abstract
Background: Cancer treatment failure is majorly attributed to the emergency of multi-drug resistance of cancer cells towards most conventional drugs used in chemotherapy hence the need for more active principles with less side effective from natural sources.
Methods: Characterization of isolated compounds was achieved using NMR spectroscopy and comparison of acquired data with literature values. The antiproliferative properties were determined using resazurin reduction assay.
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Research article
Anti-leishmanial activity of some surface compounds of Tarchonanthus camphoratus
Abstract
Background:The world health organization recognizes leishmaniasis as a major tropical disease with no effective vaccine against it. Chemotherapy, the only effective way to treat all forms of the disease, is toxic and expensive. Hence, there is need for scientists to scale up the search for new anti-leishmanial agents. The present study investigated the in vitro anti-leishmanial activity of five surface compounds of Tarchonanthus camphoratus.
Methods: The surface exudates were obt...
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Sedative, Anticonvulsant and Analgesic activities of Fresh Leaf Essential Oil of Plectranthus aegyptiacus from Southwest Nigeria in Mice
Abstract
Background: The folkloric use of Plectranthus aegyptiacus (Forssk.) C. Chr. in the Southwest Nigeria includes;pain, sensory diseases, cough and fever. This study investigated the anxiolytic, sedative, anticonvulsant and analgesic activities of the essential oil of P.aegyptiacus in mice.
Methods: The oil was extracted by hydro-distillation.5% Tween-80 (0.1 ml/10 g)was used as negative control and different standard drugs were used as positive controls depending on the model. The ...
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Protective effect of ethanolic extract and raw juice of Solanum betaceum on aluminum induced oxidative stress and associated memory deficits in rats
Abstract
Background: Oxidative stress is known to contribute to the mechanisms underpinning the pathogenesis of neurodegenerative diseases. Previous studies have identified the presence of flavonoids as the major constituents of Solanum betaceum (SB) with antioxidant activity. This work aims at investigating the protective effect of ethanolic extract and raw juice of Solanum betaceum (SB) on aluminum induced oxidative stress and associated memory deficits in Wistar rats.
Methods: Memor...
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Therapeutic Impacts of Garlic Varieties on Hyperlipidemia Induced In Male Wistar Rats
Abstract
Background: Every year, cardiovascular diseases take the lives of 17.7 million people accounting for 31% of all global deaths with atherosclerotic cardiovascular disease being the leading cause of mortality. Interestingly, hyperlipidemia is an important modifiable risk factor contributing to atherosclerosis.
Methods: Qualitative phytochemical screenings was done according to standard protocols. For hyperlipidemia protocol, animals were divided randomly into 4 groups of 6 rats eac...
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Cinnamomum zeylanicum, Dichrostachys glomerata and three other plants had anti-staphylococcal and antibiotic-modifying activity against drug-resistant phenotypes
Abstract
Background: The increase resistance of Staphylococcus aureus clinically, propels the search of novel approaches to treat staphylococcal infections. This study aims to investigate the anti-staphylococcal activity and antibiotic-modulating effects of the methanol extracts of five Cameroonian dietary plants namely Cinnamomum zeylanicum, Fagara xanthoxyloides, Imperata cylindrica, Dichrostachys glomerata, Pentadiplanara brazzeana against a panel of S. aureus strains.
Methods: The pl...
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Protective Mechanisms of Limonoids from Khaya grandifoliola against Cisplatin-Toxicity in L-02 Hepatocytes: Targeting JNK Activation and Nuclear Translocation of Nrf2
Abstract
Background: Cisplatin is one of the most effective
antineoplastic drugs, but it has undesirable side effects such as
hepatotoxicity. This study investigated in
vitro the protective activity of three limonoids known as
17-epi-methyl-6-hydroxylangolensate, 7-deacetoxy-7-oxogedunin and
deacetoxy-7R-hydroxygedunin, isolated from Khaya
grandifoliola (Meliaceae) against
cisplatin-induced hepatotoxicity and the possible mechanisms involved in this
activity.
Methods: Normal human liver...
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CYP450–mediated metabolites of aqueous leaves extract of Moringa oleifera inhibits absorption of chloroquine in Plasmodium yoeli yoeli infection
Abstract
Background: This study tested an in vivo model designed to evaluate the potential of HDI of chloroquine and aqueous leaf extract of Moringa oleifera to overcome multi-drug resistant Plasmodium yoeli yoeli infection in albino mice.
Methods: Using Rane’s test, 40 male albino mice were randomized into 10 groups of four mice each. Nine groups inoculated with multidrug-resistant strains of Plasmodium yoeli yoeli were treated with water, 150 mg/kg of Moleifera oleifera aqueous leaf extract, 1...
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Potentiation of chloroquine by antiplasmodial fraction of moringa oleifera leaves in drug resistant Plasmodium berghei infection
Abstract
Background:This study assessed changes in blood chemistry associated with co-administration of chloroquine with antiplasmodial fraction of crude methanol extract of Moringa oleifera leaves.
Methods: Partial phytochemical profiling of antiplasmodial extract was done using standard methods. Using Rane’s test, 60 male albino mice were randomized into 10 groups of six mice each. Nine groups were inoculated with quinine resistant strains of Plasmodium berghei and treated with tween 80,10mg/k...
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Antidermatophytic activity and adverse side effects of the methanolic extract from leaves of Ageratum conyzoides (Asteraceae)
Abstract
Background: The incidence of dermatophytosis has increased in recent years in spite of the availability of antifungal drugs. Faced with all the above, medicinal plants could be an alternative. So, this work aimed at evaluating antidermatophytic activities of some medicinal plants used in Cameroon against dermatophytoses.
Methods: An ethnopharmacological survey was carried out by interview of traditional healers in six villages of Bafou locality. Nine plants were selected and meth...
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