Abstract
Background: The role of nitric oxide in the pathogenesis and progression of neurodegenerative illnesses is becoming prominent over the years and the inhibition of acetylcholinesterase (AChE) is considered as a promising strategy in the management of such diseases. This study aims to assess the inhibitory potential of (1) beauvericin, (2) para-hydroxybenzaldehyde, (3) indole-3-carboxylic acid and (4) quinizarin isolated from endophytic fungi Epicoccum nigrum on acetylcholinesterase a...
More
Research article
Anti-staphylococcal activity and antibiotic-modulating effect of Olax subscorpioidea, Piper guineense, Scorodophloeus zenkeri, Fagara leprieurii, and Monodora myristica against resistant phenotypes
Abstract
Background: The development of new drugs from plants seems to be an interesting alternative approach to overcoming microbial resistance. This study aims to investigate the anti-staphylococcal and antibiotic-potentiating activity of methanolic extracts of five Cameroonian dietary plants namely Piper guineense, Fagara leprieurii, Olax subscorpioïdea, Monodora myristica and Scorodophloeus zenkeri against a panel of multidrug resistance (MDR) Staphylococcus aureus clinical isolates.
...
More
Influence of the harvesting area on the nutritional value, antioxidant and hypoglycemic properties of Spirulina platensis (Gom.) in diabetic rats (type I diabetic)
Abstract
Background: The present investigation aimed to study the effect of the harvesting area on the nutritional value, antioxidant and antidiabetic properties of Spirulina (Spirulina platensis) from five zones in type 1 diabetic rats.
Methods: Spirulina platensis was collected in dried forms from five zones (Lake Bodou, Lake Kolodorum, Lake Lactir, Lake Touffou and the wadi of Rombou) and then subjected to hydroethanolic extraction (50-50). The nutritional value, the antioxidant pote...
More
Further antibacterial compounds from Myristica fragrans
Abstract
Background: Myristica fragrans Houtt is a medicinal food plant of the family Myristicaceae. Previous phytochemical investigation of its seed kernel known as nutmeg led to the isolation of antibacterial flavonoid, 3’,4’,7-trihydroxyflavone. The present study thus aimed to identify further antibacterials of the crude methanol extract from nutmeg.
Methods: The modified rapid p-iodonitrotetrazolium chloride (INT) colorimetric assay was used to determine the Minimal Inhibitory Concent...
More
Ardisinol III, a naturally occurring alkenylmethylresorcinol displayed cytotoxic effects in carcinoma cells
Abstract
Background: Cancer is a serious health concern worldwide making the continuous discovery of new cytotoxic agents a challenging issue. In this study, the cytotoxicity of a naturally occurring alkenylmethylresorcinol, ardisinol III was evaluated in a panel of six human carcinoma cell lines and the normal fibroblasts.
Methods: The cytotoxicity of samples was evaluated by the neutral red uptake (NR) assay; the activity of caspases in breast adenocarcinoma MCF7 cells was detected by c...
More
In vivo antiplasmodial activity of extracts of selected Ghanaian medicinal plants
Abstract
Background: Malaria is endemic and perennial in all parts of Ghana. Ghana recorded 4,940,270 suspected malaria cases in the first half of the year 2016. This translates into 26,922 as an average daily recorded case of malaria in the country’s health facilities during the period.
Methods: This study investigated the antiplasmodial activities of aqueous extracts of the stem barks of Afraegle paniculata, Monanthotaxis trichocarpa, Sterculia setigera and Strychnos innocua as well as ...
More
Plants- Drug Interactions Against Some Multi-drug Resistant Microorganisms Causing Urogenital Tract Infections in Cameroon
Investigational Medicinal Chemistry and Pharmacology 2018 1(1):4
Abstract
Background: Multi drug resistance is an increasing phenomenon plaguing the use of antibiotics nowadays. This favors the spread of pathogenic microorganisms causing a major public health problem. Antimicrobial compounds from medicinal plants can be used synergistically to enhance the activity of standard drugs when used concurrently. The aim of this work was to evaluate the ability of extracts from Skirakiopsis ellip...
More
Anti-nociceptive and Anti-inflammatory Effects of Gmelina arborea Roxb. e x. Sm.
Abstract
Background: The aim of the present study was to evaluate the anti-inflammatory and anti-nociceptive activities of the methanolic extract of Gmelina arborea fruit (GAF) and stem bark (GASB) on egg-albumin induced inflammation and heated plate metal respectively.
Methods: Five hundred grams of each of the pulverised samples was extracted with 90% methanol using soxhlet extractor to produce dense mass of methanolic extracts after distillation and kept in a refrigerator at 4oC until ...
More
Polyphenolic extract of Paullinia pinnata leaf exhibits antidiabetic, anthyperlipidaemic and antioxidant activities in alloxan-induced diabetic rats
Abstract
Background: This study evaluated the antidiabetic, antihyperlipidaemic and antioxidant effects of polyphenolic extract of Paullinia pinnata leaf (PEPPL) in alloxan-induced diabetic rats.
Method: Diabetes was induced in Albino rats by intraperitoneal administration of alloxan monohydrate (120 mg/kg body weight (b. w.)). Male and female rats of average weight 150 ± 1.14 g were selected for the study. PEPPL at a dose of 25 and 50 mg/kg b. w. was administered single dose per day to a...
More
Cytotoxicity of Lupeol from the Stem Bark of Zanthoxylum gilletii against Multi-factorial Drug Resistant Cancer Cell Lines
Investigational Medicinal Chemistry and Pharmacology 2018 1(1):10.
Abstract
Background: Drug resistance is one of the major hurdles in the treatment of cancer. Rather than single factors, drug resistance is caused by multiple mechanisms making it even more complex. In the present study, the cytotoxicity of six compounds isolated from Zanthoxylum gilletii were screened against drug-sensitive leukemia CCRF-CEM cells. The most cytotoxic compound, lupeol (1) was further tested in a panel of n...
More