Abstract
Background: Uvariodendrion calophyllum is used in traditional medicine for the treatment of infectious diseases and has been shown to possess some biological properties. This study aims to assess the acute and subacute toxicological profile of the ethanolic leaf extract of Uvariodendron calophyllum (UCL EtoH).
Methods: The acute and subacute toxicity experiments on mice were done following the OECD 425 and OECD 407 standards. In the investigation on acute toxicity, mice...
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Archives
Volume8, issue 1; April 30; 2025
https-dx-doi-org-10-31183-imcp-2025-v8i1
Volume8, issue 2; August 30; 2025
https-dx-doi-org-10-31183-imcp-2024-v8i2
Volume8, issue 3; December 31; 2025
https-dx-doi-org-10-31183-imcp-2024-v8i3
Targeting larvae and odorant-binding proteins for mosquito control: Experimental and in-silico investigations of Schiff bases containing aminophenol moiety
Abstract
Background: Controlling mosquitoes is crucial for public health globally. Presently, the emphasis is on transitioning from conventional insecticides to viable alternatives such as larvicide options. This study aims to determine the effectiveness of two Schiff base compounds as larvicides and repellents for mosquito control.
Methods: The stock solution of two Schiff base compounds (Z)-2-((2-hydroxybenzylidene)amino)phenol (MO) and (Z)-4-bromo-2-(((2-hydroxyphenyl)imino)methyl)-phe...
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Combining extracts of Zingiber officinale rhizomes and dried fruits of Tetrapleura tetraptera improve oxidative stress and hematological profiles, reduces joint inflammation and hyperalgesia after carrageenan injection in rat joints
Abstract
Background: Zingiber officinale and Tetrapleura tetraptera are recognized and widely used for medicinal and nutritional qualities. The study aimed to evaluate the anti-inflammatory properties of the mixture of the aqueous and ethanolic extracts of Zingiber officinale and Tetrapleura tetraptera.
Methods: Joint inflammation induced by carrageenan (3%), the clinical signs of inflammation (paw edema) and pain (mechanical hyperalgesia and tactile allodynia), biochemical, hematological...
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Allium cepa bulbs (Alliaceae) and Syzygium aromaticum spices (Myrtaceae) aqueous extracts mixture protects the knee joint and the features associated with movement in a model of locomotor dysfunction induced by the monoidoacetate on Wistar rat
Abstract
Background: Allium cepa (Onion) is widely used as a flavored vegetable in various types of foods and against urinary system disorders, ear disorders, and injuries. Syzygium Aromaticum (clove) is used as a local anesthetic, also used against pain, rheumatological, and antioxidant problems. This study aimed to show the protective effects of the aqueous extract of the mixture of Onion and clove in the occurrence of a joint pathology such as osteoarthrosis.
Methods: The animals were ...
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Callistemon citrinus essential oil from Cameroon: potent inhibitor of bacterial respiratory pathogens without inducing resistance or persistence
Abstract
Background: Antibiotic resistance, persistent cells in respiratory infections, and adverse effects associated with antibiotics underscore the urgent need to search for alternative treatments. Natural products such as essential oils derived from aromatic plants like Callistemon citrinus may be a promising avenue to explore. This study aimed to assess the antibacterial activity of C. citrinus essential oils from two Cameroonian regions against bacteria causing respiratory infections, ...
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Translational preclinical evaluation of Strychnos innocua leaf extract: Investigating anti-nociceptive and antidepressant activities using in vivo and in silico models
Abstract
Background: Pain represents a complex physiological response of tissues to injury and often adversely impacts both health and quality of life. Epidemiological data indicate that virtually all individuals will experience some form of pain during their lifetime. Strychnos innocua (family Loganiaceae) is employed in ethnomedicine for the treatment of inflammation, pain, central nervous system disorders, and various other ailments. This study investigated the antinociceptive and antide...
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Investigation of insulin resistance and glycemic response to Dennettia tripetala essential oil in steptozocin-induced diabetic mice
Abstract
Background: The growing influence of medicinal plants among individuals living with diabetes in developing nations is a major concern for safety, efficacy, and tolerability. This study investigated the median lethal dose (LD50), antihyperglycemic effects, and potential mechanisms of action of the essential oil (EO) from the dried seeds of Dennettia tripetala (D. tripetala) in streptozocin (STZ)-induced diabetic mice.
Methods: The EO was obtained by hydrodistillation of pulverized...
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Acute toxicity evaluation of Opuntia stricta Cladode grown in Zambia on Wistar albino rodents
Abstract
Background: Traditionally, Opuntia stricta has been used to manage diabetes mellitus in many parts of the world, including Zambia. However, while a few studies elsewhere have assessed the safety of Opuntia stricta, no study to date has established its safety in Zambia. The study aimed to evaluate the acute toxicity of Opuntia Stricta cladode (OSC) on Wistar albino rodents.
Methods: At dosages of 0.5 g/kg, 1 g/kg, and 2 g/kg per os (p.o), an acute oral toxicity test was conducted ...
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In vitro antiplasmodial, anthelmintic activities and toxicological profile of the leaves, roots, and stem bark of Ficus bubu Warb
Abstract
Background: Ficus bubu is a fig tree belonging to the Moraceae family, whose leaves, roots, and stem bark contain bioactive compounds identified through qualitative and quantitative phytochemical screening. While these parts are known for their antioxidant activities, scientific data on their antiplasmodial and anthelmintic activities, as well as toxicological profiles, have not yet been reported.
Methods: Acute toxicity testing was performed on all three plant parts. Additionall...
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Comparative effects of oral antidiabetic regimens, exercise and BMI on glycemic control and organ function in type 2 diabetes mellitus patients in Bamenda, Cameroon
Background: Limited data on the impacts of oral anti-diabetic drugs (OADs) on patient vital functions are available. This study assessed the differential effects of OADs on glycemic control and hepatic and renal function in type 2 diabetes mellitus (T2DM) patients in Cameroon.
Methods: This cross-sectional study was done on 125 T2DM patients from Nkwen District Hospital, Bamenda (Cameroon). The patients’ socio-demographic characteristics and OADs were collected, while glycated hemoglobin (HbA...
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