Soursop (Annona muricata L.) seed extracts: phytochemical composition and biocontrol potential against cercosporiosis in okra (Abelmoschus esculentus L. Moech)

-Hubert Bolie; Libert Brice Tonfack; Sylvere Landry Lontsi Dida; Patrice Zemko Ngatsi; Juste Philantrope Abega; Eric Bilo’a Ndongo; Claire Stéphane Tsogo; Tize Tize; and Bekolo Ndongo.

Abstract Background: Annona muricata, or soursop, is a tropical plant known for antimicrobial and antiparasitic properties, widely used in traditional remedies. Extracts from leaves, seeds, and bark show activity against pathogens in humans and plants, making it a promising candidate for natural biopesticide development as safer alternatives to chemical controls. This study evaluates Annona muricata seed extracts as bio-fungicides against Cercospora leaf spot in okra under field conditions. ...

Seroprevalence of hepatitis C among blood donors at the National Blood Transfusion Center (NBTC) of N’Djamena in 2022: a cross-sectional and analytical study

-Abakar Hassan Gadou; Al Cherif Hamid Mahamat; Aurelie Solange Ntso Agume; Abderrazzack Adoum Fouda; Renaud Nonmarmbaye; Fangbo Bruno Amboussidi; and Nicolas Yanou Njintang

Abstract Background: In Africa, hospital blood demand is important; but inadequately managed and hence hazardous. So far, only a few studies in Chad have reported hepatitis C among blood donors and examined its influence on their clinical state. The goal of our study was to assess hepatitis C seroprevalence among blood donors at the National Blood Transfusion Center (NBTC) in Ndjamena, identify risk factors, and analyze the biochemical profile. Methods: A descriptive and cross-sectional s...

In-silico study of aminobenzoic acid Schiff base copper-complexes as potential cell inhibitors of cyclin-dependent kinase 7

-Felicia Ndidi Ejiah; Oluwafemi Segun Aina; Inemesit Asukwo Udofia; Tolulope Mojisola Fasina; and Oluwole Babafemi Familoni.

Abstract Background: Cell inhibitors are gradually becoming a tool in drug discovery as this gives a lead to potential compounds with therapeutic application. Presently, cancer cell inhibitors have shown drug-likeness based on oral bioavailability, pharmacokinetics, global chemical reactivity and theoretical binding affinities. Herein, we report copper complexes synthesized from aminobenzoic acid moiety, 3-(2-hydroxybenzylideneamino) benzoic acid copper complex and 4-(2-hydroxybenzylideneami...

Pharmacological impact of secondary metabolites of Senecio biafrae vegetable for PPARα agonist, antioxidant, hepatoprotection, hematological, histopathological and antimicrobial potential

-Zacchaeus S. Ololade; Mariam T. Akorede-Oloye; Christianah A. Akinawo; Jumoke R. Adekunbi; Adewumi I. Adeagbo; Olayinka F. Onifade; Olawumi T. Oyebanji; and Anikeola C. Olaniran.

Abstract Background: This study was aimed at investigating the in-silico and in-vivo hepatoprotective, antioxidant, and antimicrobial potential of Senecio biafrae (Olive and Hierne) C. Jeffrey (Asteraceae). Methods: The chemoinformatic assay was conducted using ligands against hepatic peroxisome proliferator-activated receptor binding protein (PPARα). Lipid examination, liver function tests, antioxidant, hematological, and histopathological examinations were studied to evaluate the hepato...

Antioxidant and antidiabetic properties, and safety profile of methanolic extract of Garcinia kola seed (bitter kola)

-Nestor Tordzagla; Emmanuel Eddie Blay; Baba Sulemana Mohammed.

Abstract Background: Diabetes mellitus is growing global health concerns and conventional treatments for diabetes present limitations, prompting exploration of alternative therapeutic approaches. Garcinia kola seed from the family Clusiaceae is known for its medicinal properties and it is used as a traditional medicine for antidiabetic management. This study aimed to investigate the phytochemicals, antioxidant and antidiabetic activities as well as safety profile of the methanolic extract of...

A combination of Psidium guajava and Aloe vera Aqueous Extracts Prevents Ethanol-Induced Gastric Ulcer in Rats through Suppression of Oxidative Stress and Gastric Inflammation

-Thiery Tania Meseme; Tanayen Julius Kihdze; Francis Desiré Tatsinkou Bomba; Eleonore Ngounou; Arnaud Fondjo Kouam; Asongalem Emmanuel Acha.

Abstract Background: Gastric ulcers are a common gastrointestinal disorder for which there is a need to search for a better prevention method or treatment options. Accordingly, this study aimed to assess the protective effect of a combination of Psidium guajava and Aloe vera extracts against ethanol-induced gastric ulcers in rats. Methods: The gastric ulcer was induced in rats using one oral dose of absolute ethanol (5 mL/kg body weight (b.w)). A combination of P. guajava and A. vera at d...