Abstract
Background: Antibiotic resistance, persistent cells in respiratory infections, and adverse effects associated with antibiotics underscore the urgent need to search for alternative treatments. Natural products such as essential oils derived from aromatic plants like Callistemon citrinus may be a promising avenue to explore. This study aimed to assess the antibacterial activity of C. citrinus essential oils from two Cameroonian regions against bacteria causing respiratory infections, ...
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Volume8, issue 2; July 31; 2025
https-dx-doi-org-10-31183-imcp-2025-v8i2
Research Article
1- Inhibitors of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase: In-silico evaluation of phenylpiperazinyl derivatives
Authors: Oluwafemi S. Aina; Mujeeb O. Rofiu; Kafayat A. Owoseni-Fagbenro; Luqman A. Adams; Oluwole B. Familoni. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):109. doi: https://dx.doi.org/10.31183/imcp.2025.00109
2- Antidiabetic effects of Cassia abbreviata Oliv. leaf fractions extracts in type 2 diabetic male adult Wistar rats
Authors: Emmanuel M. Musenge; Lavina Prashar; Sergio Muwowo; Isaac Mweemba, Victoria Mwiinga-Kalusopa; Marie-Claire Uwamahoro; and Fastone M. Goma. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):110. doi: https://dx.doi.org/10.31183/imcp.2025.00110
3- Antibacterial activity and antibiotic-potentiating effects of Termnalia laxiflora and Azadirachta indica against multidrug-resistant Staphylococcus aureus
Authors: Larissa Mpude; Eric Cadet; Derick J. Assonfack; Ancela W. B. Yendze; Jenifer R. N. Kuete; Valaire Y. Matieta; Junior F. Megaptche; Michael F. Kengne; Idrios N. Bonsou; Armelle T. Mbaveng; and Victor Kuete. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):111. doi: https://dx.doi.org/10.31183/imcp.2025.00111
4- Anti-inflammatory, analgesic, and antipyretic activities of aqueous and methanol stem bark extracts of Drypetes gossweileri in persistent inflammatory pain induced by complete Freund’s adjuvant in rats
Authors: Francis Desire Tatsinkou Bomba; Uzuegbu Esther Nyechukwu; Bibiane Aimee Wandji; Erastus Nembu Nembo; Armel Jackson Seukep; Arnaud Fodjo Kouam; Marius Mbiantcha; Telesphore Benoit Nguelefack; and Emmanuel Acha Asongalem.
Investigational Medicinal Chemistry and Pharmacology 2025 8(2):112. doi: https://dx.doi.org/10.31183/imcp.2025.00112
5- Ethanolic leaf extract of Crinum distichum reverses carbon tetrachloride-induced hepatic fibrosis in rats
Authors: Melanie Numbu; Arnaud Kouam Fondjo; Eleonore Ngounou; Elisabeth Menkem Zeuko’o; Branly-natalien Nguena-dongue; Napoleon Mfonku; and Gregory Edie Halle-Ekane. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):113. doi: https://dx.doi.org/10.31183/imcp.2025.00113
6- Comparative effects of oral antidiabetic regimens, exercise and BMI on glycemic control and organ function in type 2 diabetes mellitus patients in Bamenda, Cameroon
Authors: Junior Tegha Kum Muankang; Andre Gilles Mache; Aphrodite Choumessi Tchewonpi; Olivia Maih Tim; Christian Fusi Suh; Faustin Pascal Manfo Tsague; Promise Penn Muluh; Edouard Nantia Akono. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):114. doi: https://dx.doi.org/10.31183/imcp.2025.00114
7- In vitro antiplasmodial, anthelmintic activities and toxicological profile of the leaves, roots, and stem bark of Ficus bubu Warb.
Authors: Eugène Ekounè Kamè; Edwige Laure Nguemfo; Sandrine Evelyne Nsango; Lawrence Ayong; Else Carole Eboumbou Moukoko; Giselle Marie Marguerite Etamè Loe; and Jean Emmanuel Mbosso Teinkela. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):115. doi: https://dx.doi.org/10.31183/imcp.2025.00115
8- Acute toxicity evaluation of Opuntia stricta Cladode grown in Zambia on Wistar albino rodents
Authors: Martin Kampamba; Christian Chinyere Ezeala; Kadango Zombe; and Angela Gono Bwalya. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):116. doi: https://dx.doi.org/10.31183/imcp.2025.00116
9- Investigation of insulin resistance and glycemic response to Dennettia tripetala essential oil in steptozocin-induced diabetic mice
Authors: Tajudin Adesegun Adetunji; Abiodun Kofoworola Ajeigbe; Ummulkhair Funke Adetunji; and Idris Ajayi Oyemitan. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):117. doi: https://dx.doi.org/10.31183/imcp.2025.00117
10- Translational preclinical evaluation of Strychnos innocua leaf extract: Investigating anti-nociceptive and antidepressant activities using in vivo and in silico models
Authors: Chinedu Enegide; Eugene Ehimare; Divine Odeworitse; Ujunwa Emelda Ezeanochie; Israel Ofejiro Efejene; Michael Eromosele Aisuodionoe; Osasengo Precious Osifo; Esther Adaeze Ossai; Emmanuella Chukwufumnanya Nwegbu; Sophia Onyinyechi Agundu; and Jennifer Orevaoghene Etiku. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):118. doi: https://dx.doi.org/10.31183/imcp.2025.00118
11- Callistemon citrinus essential oil from Cameroon: potent inhibitor of bacterial respiratory pathogens without inducing resistance or persistence
Authors: Marc Flaubert Yumsu Tcham; Ebenezer Tatiekam Foka; Cedric Fossi Tchinda; Armelle Deutou Tchamgoue; Véronique Beng Penlap; and Jean Paul Assam Assam. Investigational Medicinal Chemistry and Pharmacology 2025 8(2):119. doi: https://dx.doi.org/10.31183/imcp.2025.00119
Translational preclinical evaluation of Strychnos innocua leaf extract: Investigating anti-nociceptive and antidepressant activities using in vivo and in silico models
Abstract
Background: Pain represents a complex physiological response of tissues to injury and often adversely impacts both health and quality of life. Epidemiological data indicate that virtually all individuals will experience some form of pain during their lifetime. Strychnos innocua (family Loganiaceae) is employed in ethnomedicine for the treatment of inflammation, pain, central nervous system disorders, and various other ailments. This study investigated the antinociceptive and antide...
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Investigation of insulin resistance and glycemic response to Dennettia tripetala essential oil in steptozocin-induced diabetic mice
Abstract
Background: The growing influence of medicinal plants among individuals living with diabetes in developing nations is a major concern for safety, efficacy, and tolerability. This study investigated the median lethal dose (LD50), antihyperglycemic effects, and potential mechanisms of action of the essential oil (EO) from the dried seeds of Dennettia tripetala (D. tripetala) in streptozocin (STZ)-induced diabetic mice.
Methods: The EO was obtained by hydrodistillation of pulverized...
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Acute toxicity evaluation of Opuntia stricta Cladode grown in Zambia on Wistar albino rodents
Abstract
Background: Traditionally, Opuntia stricta has been used to manage diabetes mellitus in many parts of the world, including Zambia. However, while a few studies elsewhere have assessed the safety of Opuntia stricta, no study to date has established its safety in Zambia. The study aimed to evaluate the acute toxicity of Opuntia Stricta cladode (OSC) on Wistar albino rodents.
Methods: At dosages of 0.5 g/kg, 1 g/kg, and 2 g/kg per os (p.o), an acute oral toxicity test was conducted ...
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In vitro antiplasmodial, anthelmintic activities and toxicological profile of the leaves, roots, and stem bark of Ficus bubu Warb
Abstract
Background: Ficus bubu is a fig tree belonging to the Moraceae family, whose leaves, roots, and stem bark contain bioactive compounds identified through qualitative and quantitative phytochemical screening. While these parts are known for their antioxidant activities, scientific data on their antiplasmodial and anthelmintic activities, as well as toxicological profiles, have not yet been reported.
Methods: Acute toxicity testing was performed on all three plant parts. Additionall...
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Comparative effects of oral antidiabetic regimens, exercise and BMI on glycemic control and organ function in type 2 diabetes mellitus patients in Bamenda, Cameroon
Background: Limited data on the impacts of oral anti-diabetic drugs (OADs) on patient vital functions are available. This study assessed the differential effects of OADs on glycemic control and hepatic and renal function in type 2 diabetes mellitus (T2DM) patients in Cameroon.
Methods: This cross-sectional study was done on 125 T2DM patients from Nkwen District Hospital, Bamenda (Cameroon). The patients’ socio-demographic characteristics and OADs were collected, while glycated hemoglobin (HbA...
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Ethanolic leaf extract of Crinum distichum reverses carbon tetrachloride-induced hepatic fibrosis in rats
Abstract
Background: Liver diseases are increasingly recognized as significant public health issues, with cirrhosis alone ranking 12th as the leading cause of death worldwide. This study aimed to evaluate the anti-fibrotic effects of ethanolic leaf extract of Crinum distichum (CDE) in male Wistar rats with Carbon tetrachloride (CCl4)-induced liver fibrosis.
Methods: Phytochemical profiling of CDE was assessed through High Performance Liquid Chromatography/Mass spectrometry (HPLC/MS) analy...
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Anti-inflammatory, analgesic, and antipyretic activities of aqueous and methanol stem bark extracts of Drypetes gossweileri in persistent inflammatory pain induced by complete Freund’s adjuvant in rats
Abstract
Background: Drypetes gossweileri (Euphorbiaceae) is a medicinal plant used in Cameroon to treat toothache, gastritis, and pain. This study was conducted to evaluate the anti-inflammatory, analgesic, and anti-pyretic effects of the aqueous (AEDG) and methanol (MEDG) stem bark extracts in a persistent inflammatory pain model induced by Complete Freund’s Adjuvant (CFA) in rats.
Methods: Inflammatory pain was induced by intra-plantar injection of 50 µL of CFA into the left hind paw o...
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Antibacterial activity and antibiotic-potentiating effects of Termnalia laxiflora and Azadirachta indica against multidrug-resistant Staphylococcus aureus
Abstract
Background: S. aureus is a multidrug-resistant (MDR) bacterium that poses a significant public health threat globally. In response, plants have emerged as promising alternatives in combatting infections caused by this pathogen. This study aims to evaluate the efficacy of two medicinal plants against MDR Gram-positive Staphylococcus aureus.
Methods: The antibacterial activity of various plant extracts was assessed both individually and in combination with conventional antibiotics ...
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Antidiabetic effects of Cassia abbreviata Oliv. leaf fractions extracts in type 2 diabetic male adult Wistar rats
Abstract
Background: Globally, type 2 diabetes mellitus, or diabetes, comprises over 96% of all diabetic cases. Therefore, we investigated the antidiabetic effects of Cassia abbreviata fractions of chloroform, ethyl acetate, and petroleum ether in type 2 diabetic male adult Wistar rats.
Methods: Type 2 diabetes was induced via a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) following a high-fat, high-sucrose diet. Diabetic rats were treated with different fract...
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