Abstract
Background: Uvariodendrion calophyllum is used in traditional medicine for the treatment of infectious diseases and has been shown to possess some biological properties. This study aims to assess the acute and subacute toxicological profile of the ethanolic leaf extract of Uvariodendron calophyllum (UCL EtoH).
Methods: The acute and subacute toxicity experiments on mice were done following the OECD 425 and OECD 407 standards. In the investigation on acute toxicity, mice...
More
Archives
Table of Contents
Volume8, issue 3; December 31; 2025
https-dx-doi-org-10-31183-imcp-2025-v8i3
Research Article
1- Allium cepa bulbs (Alliaceae) and Syzygium aromaticum spices (Myrtaceae) aqueous extracts mixture protects the knee joint and the features associated with movement in a model of locomotor dysfunction induced by the monoidoacetate on Wistar rat
Authors: Jovanie Destin Bakouatche; Marcelle Bejoutance Djami; Desire Francis Tatsinkou Bomba;Ernest Allah Hoki Kwenthe; William Nana Yousseu; Donatien Albert Atsamo; Carlos Yannick Tcheutchoua; Flore Miariam Kana; Marius Mbiantcha; Gilbert Ateufack; and Bertrand Alain Dongmo. Investigational Medicinal Chemistry and Pharmacology 2025 8(3):120. doi: https://dx.doi.org/10.31183/imcp.2025.00120
2- Combining extracts of Zingiber officinale rhizomes and dried fruits of Tetrapleura tetraptera improve oxidative stress and hematological profiles, reduces joint inflammation and hyperalgesia after carrageenan injection in rat joints
Authors: Marcelle Djami Bejoutance; Danielle Claude Bilanda: William Yousseu Nana; Francis Desire Bomba Tatsinkou; Albert Donatien Atsamo; Stéphanie Flore Djuichou Nguemnang; Marcelle Olga Feigni Youyou; Jovanie Destin Bakouatche; Miariam Flore Kana; Marius Mbiantcha; Gilbert Ateufack; Paul Desiré Dzeufiet Djomeni. Investigational Medicinal Chemistry and Pharmacology 2025 8(3):121. doi: https://dx.doi.org/10.31183/imcp.2025.00121
3- Targeting larvae and odorant-binding proteins for mosquito control: Experimental and in-silico investigations of Schiff bases containing aminophenol moiety
Authors: Felicia Ndidi Ejiah; Fouad Abidemi Adetoro; Oluwabusola Folake Lawal; Mujeeb Olarewaju Rofiu. Investigational Medicinal Chemistry and Pharmacology 2025 8(3):122. doi: https://dx.doi.org/10.31183/imcp.2025.00122
4- Ethanolic leaf extracts of Uvariondendron Calophyllum: investigations on acute and subacute oral toxicity
Authors: Elisabeth Menkem Zeuko’o; Rufin Marie Toghueo Kuipou; Vincent Ngouana; Michele Stella Majoumouo; Rodrigue Keumoe; Gaël Siwe Tchokomeni; and Fabrice Fekam Boyom. Investigational Medicinal Chemistry and Pharmacology 2025 8(3):123. doi: https://dx.doi.org/10.31183/imcp.2025.00123
Targeting larvae and odorant-binding proteins for mosquito control: Experimental and in-silico investigations of Schiff bases containing aminophenol moiety
Abstract
Background: Controlling mosquitoes is crucial for public health globally. Presently, the emphasis is on transitioning from conventional insecticides to viable alternatives such as larvicide options. This study aims to determine the effectiveness of two Schiff base compounds as larvicides and repellents for mosquito control.
Methods: The stock solution of two Schiff base compounds (Z)-2-((2-hydroxybenzylidene)amino)phenol (MO) and (Z)-4-bromo-2-(((2-hydroxyphenyl)imino)methyl)-phe...
More
Combining extracts of Zingiber officinale rhizomes and dried fruits of Tetrapleura tetraptera improve oxidative stress and hematological profiles, reduces joint inflammation and hyperalgesia after carrageenan injection in rat joints
Abstract
Background: Zingiber officinale and Tetrapleura tetraptera are recognized and widely used for medicinal and nutritional qualities. The study aimed to evaluate the anti-inflammatory properties of the mixture of the aqueous and ethanolic extracts of Zingiber officinale and Tetrapleura tetraptera.
Methods: Joint inflammation induced by carrageenan (3%), the clinical signs of inflammation (paw edema) and pain (mechanical hyperalgesia and tactile allodynia), biochemical, hematological...
More
Allium cepa bulbs (Alliaceae) and Syzygium aromaticum spices (Myrtaceae) aqueous extracts mixture protects the knee joint and the features associated with movement in a model of locomotor dysfunction induced by the monoidoacetate on Wistar rat
Abstract
Background: Allium cepa (Onion) is widely used as a flavored vegetable in various types of foods and against urinary system disorders, ear disorders, and injuries. Syzygium Aromaticum (clove) is used as a local anesthetic, also used against pain, rheumatological, and antioxidant problems. This study aimed to show the protective effects of the aqueous extract of the mixture of Onion and clove in the occurrence of a joint pathology such as osteoarthrosis.
Methods: The animals were ...
More