Abstract
Background: Liver injury remains a serious problem worldwide despite advances in drug research. In the perspective of searching for new natural agents that can prevent such abnormalities this study was designed to evaluate the in vivo anti-oxidative properties of the methanolic extracts of Autranella congolensis and Sapium ellypticum.
Methods: The hepatoprotective properties of the extracts were evaluated on 9 groups of 5 Wistar rats using the CCl4 model. Animals were treated oral...
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Research article
Anthelmintic resistance modifying properties of extracts of Cyperus difformis L. (Cyperiaceae)
Francis Adu1, Christian Agyare1*, George Henry Sam2, Yaw Duah Boakye1, Vivian Etsiapa Boamah1
Investigational Medicinal Chemistry and Pharmacology 2018 1(1):3
Abstract
Background: Resistance by parasites to anthelmintic drugs is known to be on the increase and little attention is paid to the subject. The aim of study was to determine the anthelmintic and helminth resistance modifying activities of methanol whole plant Cyperus difformis extract against the adult Indian worm Pherethima p...
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Catechin Derivatives from Parkia biglobosa Displayed Selective Cytotoxicity Towards Leukemia CCRF-CEM Cell Line and its P-Glycoprotein Expressing Subline CEM/ADR5000
Investigational Medicinal Chemistry and Pharmacology 2018; 1(1):2
Abstract
Background: Cancer chemotherapy is challenged by drug resistance of malignant cells. In the present work, we evaluated the cytotoxicity of four catechin derivatives, 4’-methylepigallocatechin (1), gallocatechin (2), epigallocatechin (3), epigallocatechin-3-O-gallate (4) against nine drug sensitive and multidrug resistant (MDR) cancer cell lines.
Methods: The resazurin reduction assay was used to evaluate the cyt...
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Anti-staphylococcal and antibiotic-potentiating activities of seven Cameroonian edible plants against resistant phenotypes
Hermione T. Manekeng1, Armelle T. Mbaveng1*, Gaelle S. Nguenang1, Jackson A. Seukep1, Brice E. N. Wamba1, Paul Nayim1, Ngai R. Yinkfu1, Aimé G. Fankam1 and Victor Kuete1
Investigational Medicinal Chemistry and Pharmacology 2018 1(1):7
Abstract
Background: In this study, we evaluated the anti-staphylococcal and antibiotic-potentiating activities against resistant phenotypes of seven Cameroonian dietary plants: Arachis hypogaea; Cola pachycarpa; Curcuma longa; Lycopersicon esculentum; Ma...
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Potentiation of chloroquine by antiplasmodial fraction of moringa oleifera leaves in drug resistant Plasmodium berghei infection
Abstract
Background:This study assessed changes in blood chemistry associated with co-administration of chloroquine with antiplasmodial fraction of crude methanol extract of Moringa oleifera leaves.
Methods: Partial phytochemical profiling of antiplasmodial extract was done using standard methods. Using Rane’s test, 60 male albino mice were randomized into 10 groups of six mice each. Nine groups were inoculated with quinine resistant strains of Plasmodium berghei and treated with tween 80,10mg/k...
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Antibacterial activity of four Cameroonian medicinal plants against MDR bacteria and study of mode of action
Irene Chinda Kengne1, Jean-De-Dieu Tamokou1*
Abstract
Background: The increasing number of resistant bacteria to commonly used antibiotics makes the search for new active molecules a real challenge. The aim of this study is to evaluate the antibacterial activities of crude extracts and fractions from four Cameroonian medicinal plants against multi-resistant bacteria as well their mechanisms of action.
Methods: The crude extracts were prepared by maceration in methanol. The fractionatio...
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In vitro Evaluation of Antioxidant and Anti-sickling properties of Theobroma Cacao (Sterculiaceae) extracts from East and South regions in Cameroon
Abstract
Background: Sickle cell anaemia (SCA) is a genetic disease associated with increased mortality in Africa. It generates polymerization of haemoglobin, free radicals proliferation and antioxidants deficiencies. SCA management still needs new and safe drugs. The aim of this study is to evaluate the antioxidant and anti-sickling properties of cocoa extracts from two localities of Cameroon.
Methods: T. cacao beans were collected in Bertoua and Mbalmayo They were dried, ground and then...
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