Abstract
Background: This study tested an in vivo model designed to evaluate the potential of HDI of chloroquine and aqueous leaf extract of Moringa oleifera to overcome multi-drug resistant Plasmodium yoeli yoeli infection in albino mice.
Methods: Using Rane’s test, 40 male albino mice were randomized into 10 groups of four mice each. Nine groups inoculated with multidrug-resistant strains of Plasmodium yoeli yoeli were treated with water, 150 mg/kg of Moleifera oleifera aqueous leaf extract, 1...
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Research article
Potentiation of chloroquine by antiplasmodial fraction of moringa oleifera leaves in drug resistant Plasmodium berghei infection
Abstract
Background:This study assessed changes in blood chemistry associated with co-administration of chloroquine with antiplasmodial fraction of crude methanol extract of Moringa oleifera leaves.
Methods: Partial phytochemical profiling of antiplasmodial extract was done using standard methods. Using Rane’s test, 60 male albino mice were randomized into 10 groups of six mice each. Nine groups were inoculated with quinine resistant strains of Plasmodium berghei and treated with tween 80,10mg/k...
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Antidermatophytic activity and adverse side effects of the methanolic extract from leaves of Ageratum conyzoides (Asteraceae)
Abstract
Background: The incidence of dermatophytosis has increased in recent years in spite of the availability of antifungal drugs. Faced with all the above, medicinal plants could be an alternative. So, this work aimed at evaluating antidermatophytic activities of some medicinal plants used in Cameroon against dermatophytoses.
Methods: An ethnopharmacological survey was carried out by interview of traditional healers in six villages of Bafou locality. Nine plants were selected and meth...
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Inhibitory effects of four naturally occurring compounds from Epicoccum nigrum on acetylcholinesterase activity and nitric oxide production in LPS-activated RAW 264.7 cells
Abstract
Background: The role of nitric oxide in the pathogenesis and progression of neurodegenerative illnesses is becoming prominent over the years and the inhibition of acetylcholinesterase (AChE) is considered as a promising strategy in the management of such diseases. This study aims to assess the inhibitory potential of (1) beauvericin, (2) para-hydroxybenzaldehyde, (3) indole-3-carboxylic acid and (4) quinizarin isolated from endophytic fungi Epicoccum nigrum on acetylcholinesterase a...
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Anti-staphylococcal activity and antibiotic-modulating effect of Olax subscorpioidea, Piper guineense, Scorodophloeus zenkeri, Fagara leprieurii, and Monodora myristica against resistant phenotypes
Abstract
Background: The development of new drugs from plants seems to be an interesting alternative approach to overcoming microbial resistance. This study aims to investigate the anti-staphylococcal and antibiotic-potentiating activity of methanolic extracts of five Cameroonian dietary plants namely Piper guineense, Fagara leprieurii, Olax subscorpioïdea, Monodora myristica and Scorodophloeus zenkeri against a panel of multidrug resistance (MDR) Staphylococcus aureus clinical isolates.
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Influence of the harvesting area on the nutritional value, antioxidant and hypoglycemic properties of Spirulina platensis (Gom.) in diabetic rats (type I diabetic)
Abstract
Background: The present investigation aimed to study the effect of the harvesting area on the nutritional value, antioxidant and antidiabetic properties of Spirulina (Spirulina platensis) from five zones in type 1 diabetic rats.
Methods: Spirulina platensis was collected in dried forms from five zones (Lake Bodou, Lake Kolodorum, Lake Lactir, Lake Touffou and the wadi of Rombou) and then subjected to hydroethanolic extraction (50-50). The nutritional value, the antioxidant pote...
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Further antibacterial compounds from Myristica fragrans
Abstract
Background: Myristica fragrans Houtt is a medicinal food plant of the family Myristicaceae. Previous phytochemical investigation of its seed kernel known as nutmeg led to the isolation of antibacterial flavonoid, 3’,4’,7-trihydroxyflavone. The present study thus aimed to identify further antibacterials of the crude methanol extract from nutmeg.
Methods: The modified rapid p-iodonitrotetrazolium chloride (INT) colorimetric assay was used to determine the Minimal Inhibitory Concent...
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Ardisinol III, a naturally occurring alkenylmethylresorcinol displayed cytotoxic effects in carcinoma cells
Abstract
Background: Cancer is a serious health concern worldwide making the continuous discovery of new cytotoxic agents a challenging issue. In this study, the cytotoxicity of a naturally occurring alkenylmethylresorcinol, ardisinol III was evaluated in a panel of six human carcinoma cell lines and the normal fibroblasts.
Methods: The cytotoxicity of samples was evaluated by the neutral red uptake (NR) assay; the activity of caspases in breast adenocarcinoma MCF7 cells was detected by c...
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In vivo antiplasmodial activity of extracts of selected Ghanaian medicinal plants
Abstract
Background: Malaria is endemic and perennial in all parts of Ghana. Ghana recorded 4,940,270 suspected malaria cases in the first half of the year 2016. This translates into 26,922 as an average daily recorded case of malaria in the country’s health facilities during the period.
Methods: This study investigated the antiplasmodial activities of aqueous extracts of the stem barks of Afraegle paniculata, Monanthotaxis trichocarpa, Sterculia setigera and Strychnos innocua as well as ...
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Plants- Drug Interactions Against Some Multi-drug Resistant Microorganisms Causing Urogenital Tract Infections in Cameroon
Investigational Medicinal Chemistry and Pharmacology 2018 1(1):4
Abstract
Background: Multi drug resistance is an increasing phenomenon plaguing the use of antibiotics nowadays. This favors the spread of pathogenic microorganisms causing a major public health problem. Antimicrobial compounds from medicinal plants can be used synergistically to enhance the activity of standard drugs when used concurrently. The aim of this work was to evaluate the ability of extracts from Skirakiopsis ellip...
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