Assessment of in vivo acute, subacute toxicity, in vitro anti-plasmodial activity, and UPLC-ESI-QToF-MS/MS prediction of Annickia affinis (Exell) Versteegh & Sosef (Annonaceae) roots extract

-Jean Emmanuel Mbosso Teinkela; Jaures Noumedem Kenfack; Philippe Belle Ebanda Kedi; Elvira Tachie Mekjele; Thierry Fokou Nzodjou; Noella Molisa Efange; Lawrence Ayong; Else Carole Eboumbou Moukoko; Giselle Marie Marguerite Etamè Loe; and Simone Veronique Fannang.

Abstract Background: Annickia affinis is a medicinal plant widely used in African traditional medicine to treat various diseases, including malaria. This study aimed to evaluate the toxicological profile, chemical composition, and antiplasmodial activity of the ethanolic (EtOH) root extract of Annickia affinis. Methods: Acute (14-day) and subacute (28-day) toxicity studies were conducted in accordance with guidelines 423 and 407 of the Organisation for Economic Co-operation and Developmen...

Synergistic antibacterial activity of Erigeron floribundus extracts combined with erythromycin against multidrug-resistant bacteria

-Vincent Ngouana; Mado Solange Ngo Yane; Patrick Valere Tsouh Fokou; Germaine Matsuete Takongmo; Boniface Pone Kamdem; Jean Polidor Nguetsa Demafo; Prisca Laure Nobosse Pewoupa; and Jean-De-Dieu Tamokou.

Abstract Background: This research assessed the in vitro antibacterial activity of Erigeron floribundus extracts against multidrug-resistant bacterial strains and explored their potential to enhance the effectiveness of standard antibiotics through synergistic combinations. Methods: Leaf, stem, and root crude extracts of E. floribundus were obtained using methanol and ethyl acetate. Major phytochemical groups (total phenols, flavonoids, tannins, saponins) were quantified. The antimicrobia...