Abstract
Background: Zingiber officinale and Tetrapleura tetraptera are recognized and widely used for medicinal and nutritional qualities. The study aimed to evaluate the anti-inflammatory properties of the mixture of the aqueous and ethanolic extracts of Zingiber officinale and Tetrapleura tetraptera.
Methods: Joint inflammation induced by carrageenan (3%), the clinical signs of inflammation (paw edema) and pain (mechanical hyperalgesia and tactile allodynia), biochemical, hematological, oxidative stress, and histological parameters were assessed. Also, the acute toxicity of the mixture of aqueous extracts was evaluated per os (2500 and 5000 mg/kg).
Results: Aqueous extract is non-toxic. Extracts mixture (200 mg/kg) inhibited joint edema, mechanical hyperalgesia, and tactile allodynia in a single administration until the 24th hour, then continuous administration until the 10th day of treatment. Extracts did not disrupt the hematological parameters and did not affect organ weights. Both extracts showed significant antioxidant activity on enzymatic and non-enzymatic parameters. Extracts also protected the joint against the deleterious effects and did not affect the liver and kidney tissues.
Conclusion: The activities recorded in this study confirm the traditional use of Zingiber officinale and Tetrapleura tetraptera. The extracts from these plants are a clear candidate to ensure the prevention and/or treatment of joint pathologies.
Keywords: Joint inflammation; hyperalgesia; Tetrapleura tetraptera; Zingiber officinale.
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