Abstract
Background: Uvariodendrion calophyllum is used in traditional medicine for the treatment of infectious diseases and has been shown to possess some biological properties. This study aims to assess the acute and subacute toxicological profile of the ethanolic leaf extract of Uvariodendron calophyllum (UCL EtoH).
Methods: The acute and subacute toxicity experiments on mice were done following the OECD 425 and OECD 407 standards. In the investigation on acute toxicity, mice received an oral dose of 2000 mg/kg and were monitored for the first four hours, then throughout the course of 24 hours, and once per day for 14 days. UCL EtoH was administered orally to male and female mice for 28 days at doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg body weight, respectively, in the subacute toxicity experiments. The body weight, organ weight, hematological and biochemical markers, and histological alterations were assessed.
Results: The acute toxicity of UCL EtoH revealed LD50 values >2000 mg/kg with no symptoms of mortality. The subacute toxicity of UCL EtoH at different dosages demonstrated no significant adverse responses to the organs or hematological parameters.
Conclusion: The oral lethal dose was greater than 2000 mg/kg. 400 mg/kg of the extract daily for 28 days had no observable adverse effects (NOAEL) in both male and female mice.
Keywords: Acute toxicity study; biochemical parameters; hematological parameters; subacute toxicity study; Uvariodendron calophyllum.
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