Abstract
Background: After several decades of antibiotic use, pathogenic bacteria have reached alarming levels of resistance. Staphylococcus aureus is the most common cause of nosocomial infections, and treatment is difficult owing to the advent of multidrug-resistant (MDR) strains. This motivates the search for more potent drugs. Foremost, adjuvant compounds that increase the effectiveness of conventional antibiotics are also being researched extensively. The current study examined the anti...
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Research article
Effect of vitamin D supplementation on the efficacy of anti-diabetic drugs in streptozotocin- induced albino Wistar rat model
Abstract
Background: Diabetes mellitus (DM) is a major health challenge that has reached alarming levels worldwide; and due to limitations of existing therapies, the disease has remained an enduring public threat for several decades. Vitamin D deficiency has been shown to play an important role in the pathogenesis of diabetes mellitus as it can affect several key processes in the development of diabetes and its complications, such as pancreatic insulin secretion, peripheral insulin resistanc...
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Unveiling the antibacterial potential and antibiotic-resistance breaker activity of Syzygium jambos (Myrtaceae) towards critical-class priority pathogen Klebsiella isolates
Abstract
Background: Klebsiella has developed multiple-drug resistance (MDR) to a wide range of medicines, including carbapenems and third generation cephalosporins which are often regarded as the most effective drugs against MDR bacteria. The present study examined the anti-klebsiella, modes of action, and antibiotic-resistance reversal potential of Syzygium jambos (Myrtaceae) leaf (SJL) and bark (SJB) methanol extracts towards a panel of sixteen MDR K. pneumoniae and K. oxytoca strains and...
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Psidium guajava (Myrtaceae) re-sensitizes multidrug-resistant Pseudomonas aeruginosa over-expressing MexAB-OprM efflux pumps to commonly prescribed antibiotics
Abstract
Background: Pseudomonas aeruginosa is a critical-class priority pathogen showing high resistance to almost all classes of conventional antibiotics. As a result, discovering new drugs capable of combating Pseudomonas infections becomes critical. The current study looked at the antibacterial and antibiotic-resistance reversal properties of the leaf (PGL) and bark (PGB) methanol extracts of Psidium guajava (Myrtaceae), a popular food plant, towards multidrug-resistant (MDR) P. aeruginosa ...
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In vivo assessment of antidiabetic activity and safety of polyherbal teas from selected Cameroonian medicinal plants: Persea americana, Ageratum conyzoides, and Mangifera indica
Background: Diabetes mellitus (DM) is a metabolic disorder of the endocrine system which results in persistently high blood glucose levels. Available control measures do not completely cure the disease and most patients in the tropics cannot afford diabetes drugs regularly. Amongst other plants, Mangifera indica (MI), Persea americana (PA), and Ageratum conyzoides (AC) are used individually as traditional medicine by most people for the management of diabetes. This work was set to produce polyhe...
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Antibacterial potential and modes of action of botanicals from Momordica foetida (Cucurbitaceae) against multidrug-resistant bacteria expressing active efflux pumps
Abstract
Background: Momordica foetida (cucurbitaceae) known as a bitter cucumber in Cameroon is used as a medicinal plant. This plant is widely used in the treatment of microbial infections, diabetes, hypertension, stomach, and intestinal irritation. The leaves are also used to treat malaria, earache, and toothache. This study aimed at investigating the antibacterial activity of the methanol extract of M. foetida seeds against multidrug-resistant bacteria expressing active efflux pumps and ...
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Antiproliferative, antimicrobial, antiplasmodial, and oral acute toxicity of Ficus elastica Roxb. Ex Hornem lianas
Abstract
Background: Ficus elastica is a plant used in traditional medicine for the treatment of allergies and skin infections. This study aimed to investigate the antimicrobial, antiplasmodial, and antiproliferative activities of the crude extract and fraction of F. elatica as well as the study of the in vivo oral acute toxicity of the most active fraction.
Methods: The antimicrobial activity of the total extract and the different fractions was evaluated by the determination of the inhib...
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Anti-staphylococcal and antibiotic-potentiating activities of botanicals from nine Cameroonian food plants towards multidrug-resistant phenotypes
Abstract
Background: Staphylococcus aureus is a commensal and pathogenic bacterium responsible for both community and nosocomial infections, superficial or deep, and benign or lethal. Staphylococcus aureus is a commensal and pathogenic bacterium responsible for both community and nosocomial infections, superficial or deep, and benign or lethal. Because of its infectious potential and its ability to develop resistance to many antibiotics, staphylococcal infections remain the target of reinfor...
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Botanicals from nine selected Cameroonian edible plants displayed Anti-pseudomonas effects and potentiated the activities of antibiotics against multidrug-resistant phenotypes over-expressing MexAB-OprM efflux pumps
Abstract
Background: Despite the recognized efficiency of antibiotic therapy, the annual cases of deaths related to bacterial diseases is still growing in developing countries. In the present study, the in vitro antipseudomonal activity of the methanol extracts of nine food plants from Cameroon against the multidrug-resistant strains and isolates of Pseudomonas aeruginosa overexpressing active efflux pumps was determined. These plants included Persea americana, Syzygium jambos, Mangifera ind...
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Anti-Klebsiella and antibiotic-potentiation activities of the methanol extracts of seven Cameroonian dietary plants against multidrug-resistant phenotypes over-expressing AcrAB-TolC efflux pumps
Abstract
Background: Bacterial infections continue to wreak havoc around the world with high death rates. African medicinal plants and the phytoconstituents showed high efficiency in impeding the growth of the resistance phenotypes of bacteria The present work was designed to determine the antibacterial activity of seven Cameroonian dietary plants against clinical MDR isolated of Klebsiella sp. These plants included Persea americana Miller (Lauraceae), Psidium guajava Linn. (Myrtaceae), Mang...
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