Characterization and phytotherapeutic exploration of antimalarial, antioxidant and antimicrobial derivatives from biosynthesized phytochemicals inherent in the leaves of Calophyllum inophyllum

-Zacchaeus S. Ololade; Oluwatope O. Idowu; Labunmi Lajide; Funmilayo J. Gbenga-Fabusiwa-Agbaje; Felix O. Afolabi; Emmanuel A. Akintunde; Iyaduuni I. Anuoluwa; Favour O. Ololade; Gabriel O. Orodepo; Patience U. Daikwo; Tunbi D. Ojo; Lydia D. Azeez-Olaleye; and Richard A. Oyero.

Abstract Background: Calophyllum inophyllum L. (Calophyllaceae) is a medicinal plant traditionally used for infectious, inflammatory, and skin-related disorders. This study evaluated the phytochemical composition and antimalarial, antioxidant, and antimicrobial activities of its leaf extract, with emphasis on bioactive constituents. Methods: The extract was characterized using HPLC, GC-MS, AAS, and FTIR. Antimalarial activity was evaluated in vitro against Plasmodium falciparum, while doc...

Modulatory effects of hydromethanolic leaf extract of Craterispermum schweinfurthii on the female reproductive cycle in Wistar rats

-Friday Saronee; Karibo Amakiri Okari; and Tolunigba Abisola Kolawole.

Abstract Background: The estrous cycle is a set of recurring physiological changes induced by reproductive hormones in female animals. This study investigated the potential modulatory effects of the hydromethanol leaf extract of Craterispermum schweinfurthii on the female reproductive cycle using Wistar rats as experimental models. Methods: A total of 20 female Wistar rats weighing 100–250g were randomly divided into four groups of five rats each and treated as follows: Group A: Negative...