Abstract
Background: Arsenic toxicity remains a major environmental and pharmacological concern in sub-Saharan Africa, with limited safe antidotes. Chronic exposure induces oxidative stress, hematologic dysfunction, and multi-organ injury through redox imbalance. Saccharomyces cerevisiae var. boulardii (SCb), a β-glucan-rich probiotic yeast, possesses antioxidant and immunomodulatory properties that may mitigate arsenic toxicity. This study combined in vivo and in silico approaches to elucid...
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Archives
Volume 9, issue 1; January 31; 2026
https-dx-doi-org-10-31183-imcp-2026-v9i1
Volume 9, issue 2; July 31; 2026
https-dx-doi-org-10-31183-imcp-2026-v9i2
Volume 9, issue 3; December 31; 2026
https-dx-doi-org-10-31183-imcp-2026-v9i3
Cardioprotective effects of hydroalcoholic extract from Cinnamomum zeylanicum stem bark against isoproterenol-induced myocardial infarction in rats
Abstract
Background: The pharmacological properties of Cinnamomum zeylanicum have been predominantly explored in the context of cardiovascular diseases. Given its well-established anti-inflammatory and antioxidant properties, this study aimed to evaluate the cardioprotective potential of the hydroalcoholic extract of Cinnamomum zeylanicum barks (HECZ) against isoproterenol (ISO) induced cardiotoxicity.
Methods: Rats were pre-treated with HECZ (200 - 400 mg/kg, p.o.) or 100 mg/kg of vitami...
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Chemical profiling, molecular docking, and ADMET evaluation of Bougainvillea formosa stem and root barks essential oils
Abstract
Background: Essential oils have been recognized for their pharmaceutical applications as natural antioxidants. A combination of experimental and theoretical analyses was conducted on Bougainvillea formosa (B. formosa) stem and root barks essential oils.
Methods: The essential oils obtained through hydro-distillation were identified and quantified using gas chromatography–mass spectrometry (GC-MS) and were found to exhibit different compositions. The antioxidant capacity of the es...
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