Antiproliferative, antimicrobial, antiplasmodial, and oral acute toxicity of Ficus elastica Roxb. Ex Hornem lianas

-Jean Emmanuel Mbosso Teinkela; Gaelle Wea Tchepnou; Caroline Ngo Nyobe; Yannick Fouokeng; Emmanuel Mpondo Mpondo; Jules Clément Assob Nguedia

Abstract Background: Ficus elastica is a plant used in traditional medicine for the treatment of allergies and skin infections. This study aimed to investigate the antimicrobial, antiplasmodial, and antiproliferative activities of the crude extract and fraction of F. elatica as well as the study of the in vivo oral acute toxicity of the most active fraction. Methods: The antimicrobial activity of the total extract and the different fractions was evaluated by the determination of the inhib...

Phytochemistry and pharmacology of Imperata cylindrica: A comprehensive review

-Paul Nayim; Armelle T. Mbaveng; Krishna Sudhir; Brice E. N. Wamba; Mukherjee Sanjukta; Kuete V.

Abstract Background: Imperata cylindrica is a medicinal spice used in traditional medicine to cure several ailments including cancer, wounds, hypertension, and inflammation. The current study aimed to compile phytochemicals and pharmacological data on Imperata cylindrica. Methods: A bibliographic study was carried out by analyzing conventional textbooks, authentic published studies, and consulting wide-reaching accepted scientific databases. In this review, an attempt is being made to est...

Anti-staphylococcal and antibiotic-potentiating activities of botanicals from nine Cameroonian food plants towards multidrug-resistant phenotypes

-Boris Ekamgue; Armelle T. Mbaveng; Victor Kuete

Abstract Background: Staphylococcus aureus is a commensal and pathogenic bacterium responsible for both community and nosocomial infections, superficial or deep, and benign or lethal. Staphylococcus aureus is a commensal and pathogenic bacterium responsible for both community and nosocomial infections, superficial or deep, and benign or lethal. Because of its infectious potential and its ability to develop resistance to many antibiotics, staphylococcal infections remain the target of reinfor...

Botanicals from nine selected Cameroonian edible plants displayed Anti-pseudomonas effects and potentiated the activities of antibiotics against multidrug-resistant phenotypes over-expressing MexAB-OprM efflux pumps

-Romario S. Tiotsop; Victor Kuete; Armelle T. Mbaveng

Abstract Background: Despite the recognized efficiency of antibiotic therapy, the annual cases of deaths related to bacterial diseases is still growing in developing countries. In the present study, the in vitro antipseudomonal activity of the methanol extracts of nine food plants from Cameroon against the multidrug-resistant strains and isolates of Pseudomonas aeruginosa overexpressing active efflux pumps was determined. These plants included Persea americana, Syzygium jambos, Mangifera ind...

Anti-Klebsiella and antibiotic-potentiation activities of the methanol extracts of seven Cameroonian dietary plants against multidrug-resistant phenotypes over-expressing AcrAB-TolC efflux pumps

-Valaire Y. Matieta, Victor Kuete; Armelle T. Mbaveng

Abstract Background: Bacterial infections continue to wreak havoc around the world with high death rates. African medicinal plants and the phytoconstituents showed high efficiency in impeding the growth of the resistance phenotypes of bacteria The present work was designed to determine the antibacterial activity of seven Cameroonian dietary plants against clinical MDR isolated of Klebsiella sp. These plants included Persea americana Miller (Lauraceae), Psidium guajava Linn. (Myrtaceae), Mang...

In vitro screening of the potential of six Cameroonian medicinal plants on male reproductive biomarkers

-Paulin Teko Keumedjio; Sara N. Edjenguèlè Béboy; Paul Fewou Moundipa.

Abstract Background: Male infertility and erectile dysfunction are the main conditions associated with male reproductive function disorders. Testosterone is the main hormone that regulates male reproductive function, while nitric oxide is a potent vasodilator involved in the erectile process. Methods: This study was conducted to evaluate in vitro the potential of the aqueous extract of six Cameroonian medicinal plants traditionally used for male reproductive function: Palisota ambigua, Te...

In-vitro anti-salmonella activity of methanol and aqueous extracts and their associations of Psidium guajava and Carica papaya leaves

-Tashie Evangeline Ngwanguong; Gerald Ngo Teke; Stephen Lacmata Tamekou; Metoh Theresia Njuabe; Jules-Roger Kuiate.

Background: Typhoid fever is a major public health problem and endemic especially in some developing countries. The present study was aimed at determining the anti-salmonella potentials of Psidium guajava (PG) and Carica papaya (CP) leaves extract association in-vitro. Methods: The plant materials were extracted both in methanol and water separately. The methanol extract was concentrated using a rota-evaporator while the aqueous was dried in an oven. Phytochemical screening was done for the p...

Comparative study of potent anti-amoebic and anti-inflammatory activities of different extracts from Sida rhombifolia (L)

-Sylvain Pechangou Nsangou; Roukayatou Ndiandoukoue Ndam; Emmanuel Mfotie Njoya; Brice E. Enang II; Frederic N. Njayou; Paul Fewou Moundipa

Background: Sida rhombifolia (L) is a medicinal plant from tropical regions belonging to the Malvaceae family and the plantea kingdom. It is known for its multiple pharmacological properties. The aim of this work was to evaluate the anti-amoebic, and anti-inflammatory potential of Sida rhombifolia aqueous and ethanolic leaf and stem extracts harvested in two localities of Cameroon (Yaoundé and Massangam in the Centre and West regions, respectively). Methods: The anti-amoebic activity was evaluat...