Table of Contents
Volume3, issue 2; December 31, 2020
(Available at: https://www.investchempharm.com/volume/volume3/issue-2/)
https://dx.doi.org/10.31183/imcp.2020.v3i2
Research Article
1- Antidepressant potential of butanol fraction of Milicia excelsa (Moraceae) leaf in mice.
Authors: Lateef A. Akinpelu; Julius K. Olaonipekun; Samuel S. Agboola; Theophilus. A. Adegbuyi; Idowu J. Olawuni; Idris A. Oyemitan; Gbola Olayiwola. Investigational Medicinal Chemistr...
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Mechanisms of action of roots crude extract and adianthifolioside GS1 from Albizia adianthifolia (Fabaceae) against MDR Gram-negative enteric bacteria
Abstract
Background: The Cameroonian pharmacopoeia is full of many plants used amongst population to treat various infections. Albizia adianthifolia (Schum.) is one of these plants and therefore several previous studies have reported the antibacterial activities of the crude methanol extract of the roots of this plant as well as those of some of its isolated compounds. In this study, the methanol root extract, and its isolated compound "adianthifolioside GS1" were evaluated on bact...
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Antiamnesic effect of aqueous lyophilisate of Drymaria cordata on scopolamine-induced amnesia and oxidative stress in mice
Abstract
Background: Learning and memorization are the so-called higher functions of the brain whose alteration is at the origin of neurodegenerative diseases. Drymaria cordata (D. cordata) is a plant used in Cameroon to treat disorders such as convulsions and ulcers. The aim of this study was to evaluate the anti-amnestic effects of D. cordata on scopolamine-induced amnesia in mice and its potential antioxidant properties.
Methods: The Morris water maze was used to evaluate the spatial m...
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Chemical composition and antimicrobial activity of essential oils of Amomum glabrum S.Q.Tong (Zingiberaceae) from Vietnam
Abstract
Background: Vietnam is a tropical country blessed with many plants. The majority of these floras have not been exploited for their chemical constituents and biological potential. In an attempt to source for natural products to combat microbial infections, plant products can act in this regard. The aim of this paper was to report the chemical composition and antimicrobial activity of essential oil from Amomum glabrum growing in Vietnam.
Methods: The leaves and rhizomes of Amomum g...
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Characterization of phytochemicals from the root extract of Milletia leucantha and their weak anti-microbial properties
Abstract
Background: Cures for infectious diseases are slowly becoming elusive due to resistance mechanisms of disease-causing microbes. As a result, most conventional medicines are now being rendered ineffective, causing increased difficulty in the treatment of infections and an upsurge of fatalities. In the present study, the anti-bacterial and anti-fungal properties of extracts and compounds of Milletia leucantha were investigated.
Methods: The roots of M. leucantha were exhaustively e...
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Investigation of the antihyperlipidemic property of Raphia hookeri mesocarp oil in high-lard diet (HLD) fed rats
Abstract
Background: Dyslipidemia is an important risk factor cardiovascular disease. The mesocarp of R. hookeri has been shown to resemble that of palm oil in term oil quality, with a large quantity of linoleic acid (47.3%) followed by palmitic acid (32.3%), oleic acid (13.7%) and alpha-linolenic acid (1.1%). The present investigation aimed to evaluate the antihyperlipidemic property of crude Raphia hookeri mesocarp oil in male Wistar albino rats fed with high-lard diet (HLD).
Methods:...
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Antidepressant potential of butanol fraction of Milicia excelsa (Moraceae) leaf in mice
Abstract
Background: Milicia excelsa is used to treat mental illnesses among the Hausa ethnic group of Northern Nigeria, but there is lack of scientific investigation to validate this ethnomedicinal claim. Hence, this study investigated the antidepressant-like effect of butanol fraction of Milicia excelsa leaves in mice (BFME).
Methods: The antidepressant-like effect of BFME was investigated using forced swim (FST) and tail suspension (TST) tests in mice. The probable neural mec...
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Antibacterial, antioxydant and antidiarrheal properties of Tristemma hirtum P. beauv.
Abstract
Background: The aim of this study was to investigate the antibacterial, radical-scavenging and antidiarrheal properties of Tristemma hirtum.
Methods: The methanol extract of Tristemma hirtum was prepared by successive fractionation in hexane and ethyl acetate solvents. The phytochemical composition of crude extract and fractions was studied using standard methods. Their antimicrobial activities were evaluated against Gram-negative and Gram-positive species of pathogenic bacteria ...
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Table of Contents _ Volume3, issue 1; July 31, 2020
Volume3, issue 1; July 31, 2020
(Available at: https://www.investchempharm.com/volume/volume3/issue-1/)
https://dx.doi.org/10.31183/imcp.2020.v3i1
Research Article
1- Antipsychotic and anticonvulsant effects of crude aqueous leaf extract of Vitex doniana Sweet (Verbenaceae) In mice
Authors: Joshua Oloruntobi Imoru, Idris Ajayi Oyemitan and Atanda Moses Akanmu. Investigational Medicinal Chemistry and Pharmacology 2020 3(1):35. doi: https://dx.doi.org/10.31183/imcp.2020.00034
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Antimicrobial and antioxidant activities of isolated compounds from the root bark of Croton pseudopulchellus (Euphorbiaceae)
Abstract
Background: Despite the significant progress made in microbiology and the control of microorganisms, sporadic incidents of epidemics due to drug resistant microorganisms pose an enormous threat to public health. Hence, search for new antimicrobial is very important to overcome microbial resistance and emerging pathogenic bacteria and fungi. In this study, we designed to describe the isolation, structure elucidation, antimicrobial and antioxidant activities of components from the roo...
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