Abstract
Background: The objective of this study was to evaluate the in vitro antibacterial activity of nanoemulsions based on the essential oils of Canarium schweinfurthii and Dacryodes edulis against enteric bacteria responsible for diarrhea.
Methods: The essential oils were extracted by the hydrodistillation method using a Clevenger-type apparatus, and the chemical composition was determined by gas chromatography with flame ionization detection (GC-FID) and gas chromatography (GC) coup...
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Table of Contents
Volume 9, issue 1; January 31; 2026
https-dx-doi-org-10-31183-imcp-2026-v9i1
Review Article
1- Nanodrugs therapy for combating antimicrobial resistance: a review on green silver nanoparticles
Authors: Israel O. David; Samson O. Alayande; Enok O. Dare; Fatai O. Oladoyinbo; Gabriel A. Adedeji; and Abel A. Babatunde. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):128. doi: https://dx.doi.org/10.31183/imcp.2026.00128
Research Article
1- Chemical profiling, molecular docking, and ADMET evaluation of Bougainvillea formosa stem and root barks essential oils
Authors: Oluwakayode Olubunmi Odeja; Israel Azogor Ekoro; Michael Gabriel Ibok; Ejike Onwudiegwu Okpala; Christiana Ene Ogwuche; Honesty Bamidele Akpeji; and Caleb Ohirhian. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):124. doi: https://dx.doi.org/10.31183/imcp.2026.00124
2- Cardioprotective effects of hydroalcoholic extract from Cinnamomum zeylanicum stem bark against isoproterenol-induced myocardial infarction in rats
Authors: Albert Donatien Atsamo; Mireille Flaure Metchi Donfack; Gwladys Nyanga Nkomo; Marius Mbiantcha; Fidèle Ntchapda; and Théophile Dimo. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):125. doi: https://dx.doi.org/10.31183/imcp.2026.00125
3- Pharmacological and molecular insights into β-glucan-rich Saccharomyces cerevisiae var. boulardii: In vivo and in silico protection against arsenic-induced redox and hematologic imbalance
Authors: Moses Blessing Thomas; Muankang Junior Tegha Kum; Orhonigbe Innocent; Ozougwu Vincent; Ogara Amaechi; Ugwuene Francis; Agwu Linus, Uhuo Emmanuel; Achi Ngozi; Onoyima Samson; Onoja Remiguis; Ike Mmesoma; and Parker Elijah Joshua. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):126. doi: https://dx.doi.org/10.31183/imcp.2026.00126
4- Investigation of heavy and trace metals contamination in palm wine and locally brewed alcohol from the Ashanti Region of Ghana
Authors: Moses Atosiko Agbala; Joseph Kwasi Adu; and John Nii Adotey Addotey. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):127. doi: https://dx.doi.org/10.31183/imcp.2026.00127
5- Prevalence of asymptomatic carriage of plasmodium falciparum among blood donors at the Biyem-Assi District Hospital in Yaounde, Cameroon
Authors: Jaures Arnaud Noumedem Kenfack; Doriane Esther Djeussi; Cedric Yamssi; Cunegonde Kouogoue Fobasso; Jemimah Sandra Tientcheu Noutong; Abdel Azizi Mounvera; and Christelle Nadia Noumedem Anangmo. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):129. doi: https://dx.doi.org/10.31183/imcp.2026.00129
6- Antidiabetic and antioxidant potential of powder blend of Vigna subterranea, Curcuma longa, and Piper nigrum in streptozotocin-induced rats
Authors: Clautilde Teugwa Mofor; Efraїm Allah-Hissem; Denis Zofou; Florian Amel Tekou; and Jean Paul Dzoyem. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):130. doi: https://dx.doi.org/10.31183/imcp.2026.00130
7- Synergistic antibacterial activity of Erigeron floribundus extracts combined with erythromycin against multidrug-resistant bacteria
Authors: Vincent Ngouana; Mado Solange Ngo Yane; Patrick Valere Tsouh Fokou; Germaine Matsuete Takongmo; Boniface Pone Kamdem; Jean Polidor Nguetsa Demafo; Prisca Laure Nobosse Pewoupa; and Jean-De-Dieu Tamokou. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):131. doi: https://dx.doi.org/10.31183/imcp.2026.00131
8- Assessment of in vivo acute, subacute toxicity, in vitro anti-plasmodial activity, and UPLC-ESI-QToF-MS/MS prediction of Annickia affinis (Exell) Versteegh & Sosef (Annonaceae) roots extract
Authors: Jean Emmanuel Mbosso Teinkela; Jaures Arnaud Noumedem Kenfack; Philippe Belle Ebanda Kedi; Elvira Tachie Mekjele; Thierry Fokou Nzodjou; Noella Molisa Efange; Lawrence Ayong; Else Carole Eboumbou Moukoko; Giselle Marie Marguerite Etamè Loe; and Simone Veronique Fannang. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):132. doi: https://dx.doi.org/10.31183/imcp.2026.00132
9- Evaluation of anti-staphylococcal activity and acute toxicity of hexane extracts of Macaranga occidentalis (Mull. Arg.) Mull. Arg (Euphobiaceae)
Authors: Prosper E. K. Lele; Soreille R. Y. Sofeu; Aimé G. Fankam; Jason B. T. Kuete; Remi R. Nsatar; and Victor Kuete. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):133. doi: https://dx.doi.org/10.31183/imcp.2026.00133
10- Acute and subchronic toxicity of the aqueous extract of Bauhinia thonningii (Caesalpiniaceae) Schum pods
Authors: Rick P.T. Bitchebe; Moïse L. Nchouwet; Sylviane L.K. Poualeu; Liliane M.T. Tchoumba; Marius T. K. Wego; Rostand C.D. Douho; and Sylvie L. N. Wansi. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):134. doi: https://dx.doi.org/10.31183/imcp.2026.00134
11- Investigating the ethanolic extract of Desmodium uncinatum as a natural protector in streptozotocin-induced diabetic nephropathy in Wistar rats
Authors: Jordane W. Kamgaing; Sylviane L. K. Poualeu; Moïse L. Nchouwet; Lylie G. M. Atsafack; Rostand C. D. Douho; and Sylvie L. N. Wansi
Investigational Medicinal Chemistry and Pharmacology 2026 9(1):135. doi: https://dx.doi.org/10.31183/imcp.2026.00135
12- Nanoemulsions of Canarium schweinfurthii sap and Dacryodes edulis kernel essential oils: Chemical profile and in vitro efficacy against diarrheagenic bacteria
Authors: Jaurès Arnaud Noumedem Kenfack; Vincent Ngouana; Doriane E. Djeussi; Joel Nanda Kamassop; and Pierre Michel Jazet Dongmo. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):136. doi: https://dx.doi.org/10.31183/imcp.2026.00136
Investigating the ethanolic extract of Desmodium uncinatum as a natural protector in streptozotocin-induced diabetic nephropathy in Wistar rats
Abstract
Background: Diabetic nephropathy is a severe microvascular complication of type 1 diabetes, often leading to chronic kidney disease. This study aimed to evaluate the renoprotective effects of the ethanolic extract of Desmodium uncinatum (EEDU) on renal dysfunction in streptozotocin-induced diabetic rats.
Methods: Type 1 diabetes was induced in male rats via intraperitoneal injection of a single dose of streptozotocin (STZ) at 60 mg/kg. After 72 hours, only animals with blood gluc...
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Acute and subchronic toxicity of the aqueous extract of Bauhinia thonningii (Caesalpiniaceae) Schum pods
Abstract
Background: Bauhinia thonningii is traditionally used to treat bacterial infections, dysentery, and diarrhea. The present study aimed to evaluate the acute and subchronic toxicity of the aqueous extract of B. thonningii pods.
Methods: Acute toxicity was evaluated according to Organisation for Economic Co-operation and Development (OECD) guideline 423 in Wistar rats receiving single oral doses of 2000 or 5000 mg/kg of the aqueous extract. Subchronic toxicity was assessed...
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Evaluation of anti-staphylococcal activity and acute toxicity of hexane extracts of Macaranga occidentalis (Mull. Arg.) Mull. Arg (Euphobiaceae)
Abstract
Background: Macaranga occidentalis is well known in traditional medicine for the treatment of various ailments like bruises, boils, cuts, sores, and diarrhea. This study aimed to investigate in vitro and in vivo the anti-staphylococcal activity of Macaranga occidentalis extracts on selected Staphylococcus aureus, including multidrug resistance (MDR) isolates. Moreover, the acute toxicity of the active extract was assessed.
Methods: Extracts were prepared by maceration of M. occid...
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Assessment of in vivo acute, subacute toxicity, in vitro anti-plasmodial activity, and UPLC-ESI-QToF-MS/MS prediction of Annickia affinis (Exell) Versteegh & Sosef (Annonaceae) roots extract
Abstract
Background: Annickia affinis is a medicinal plant widely used in African traditional medicine to treat various diseases, including malaria. This study aimed to evaluate the toxicological profile, chemical composition, and antiplasmodial activity of the ethanolic (EtOH) root extract of Annickia affinis.
Methods: Acute (14-day) and subacute (28-day) toxicity studies were conducted in accordance with guidelines 423 and 407 of the Organisation for Economic Co-operation and Developmen...
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Synergistic antibacterial activity of Erigeron floribundus extracts combined with erythromycin against multidrug-resistant bacteria
Abstract
Background: This research assessed the in vitro antibacterial activity of Erigeron floribundus extracts against multidrug-resistant bacterial strains and explored their potential to enhance the effectiveness of standard antibiotics through synergistic combinations.
Methods: Leaf, stem, and root crude extracts of E. floribundus were obtained using methanol and ethyl acetate. Major phytochemical groups (total phenols, flavonoids, tannins, saponins) were quantified. The antimicrobia...
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Antidiabetic and antioxidant potential of powder blend of Vigna subterranea, Curcuma longa, and Piper nigrum in streptozotocin-induced rats
Abstract
Background: Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and frequently associated with oxidative stress and metabolic complications. The present study evaluated the antidiabetic and antioxidant potential of a powder blend composed of Vigna subterranea, Curcuma longa, and Piper nigrum in streptozotocin-induced diabetic rats.
Methods: A mixture design approach was used to optimize the formulation of the powder blend based on total phe...
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Prevalence of asymptomatic carriage of plasmodium falciparum among blood donors at the Biyem-Assi District Hospital in Yaounde, Cameroon
Abstract
Background: Malaria is transmitted by the bite of a female Anopheles mosquito, interhuman (transplacental), and by blood transfusion. The present study aimed to determine the prevalence of Plasmodium parasitemia among blood donors at the Biyem-Assi district hospital in Yaounde.
Methods: This was a descriptive and analytical study conducted on 267 blood donors recruited at the blood bank of the Biyem-Assi District Hospital over 3 months, from February to May 2024. To obtain the fr...
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Nanodrugs therapy for combating antimicrobial resistance: a review on green silver nanoparticles
Abstract
Background: A nanotechnology-based approach offers researchers an opportunity to address the challenges of antimicrobial resistance. In this review, we summarize the antimicrobial properties, mechanisms, current synthesis trends, and limitations of green silver nanoparticles.
Methods: The review examines a wide range of scientific databases, such as ScienceDirect, Scopus, PubMed, Google Scholar, and Web of Science, to assess the effectiveness, mechanisms of action, and synthesis ...
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Investigation of heavy and trace metals contamination in palm wine and locally brewed alcohol from the Ashanti Region of Ghana
Abstract
Background: Palm wine and locally produced alcoholic beverages are widely consumed in rural communities in Africa, due to their perceived health benefits. However, their safety regarding heavy and trace metal contamination is lacking, particularly in Ghana. This study quantitatively assessed heavy-metal contamination in fresh palm wine (FPW), fermented palm wine (FEPW), freshly brewed alcohol (FAL), and stored alcohol (SAL) from 5 brewing sites in the Ashanti region of Ghana.
Met...
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