Abstract
Background: Arsenic toxicity remains a major environmental and pharmacological concern in sub-Saharan Africa, with limited safe antidotes. Chronic exposure induces oxidative stress, hematologic dysfunction, and multi-organ injury through redox imbalance. Saccharomyces cerevisiae var. boulardii (SCb), a β-glucan-rich probiotic yeast, possesses antioxidant and immunomodulatory properties that may mitigate arsenic toxicity. This study combined in vivo and in silico approaches to elucid...
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Volume 9, issue 1; January 31; 2026
https-dx-doi-org-10-31183-imcp-2026-v9i1
Review Article
1- Nanodrugs therapy for combating antimicrobial resistance: a review on green silver nanoparticles
Authors: Israel O. David; Samson O. Alayande; Enok O. Dare; Fatai O. Oladoyinbo; Gabriel A. Adedeji; and Abel A. Babatunde. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):128. doi: https://dx.doi.org/10.31183/imcp.2026.00128
Research Article
1- Chemical profiling, molecular docking, and ADMET evaluation of Bougainvillea formosa stem and root barks essential oils
Authors: Oluwakayode Olubunmi Odeja; Israel Azogor Ekoro; Michael Gabriel Ibok; Ejike Onwudiegwu Okpala; Christiana Ene Ogwuche; Honesty Bamidele Akpeji; and Caleb Ohirhian. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):124. doi: https://dx.doi.org/10.31183/imcp.2026.00124
2- Cardioprotective effects of hydroalcoholic extract from Cinnamomum zeylanicum stem bark against isoproterenol-induced myocardial infarction in rats
Authors: Albert Donatien Atsamo; Mireille Flaure Metchi Donfack; Gwladys Nyanga Nkomo; Marius Mbiantcha; Fidèle Ntchapda; and Théophile Dimo. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):125. doi: https://dx.doi.org/10.31183/imcp.2026.00125
3- Pharmacological and molecular insights into β-glucan-rich Saccharomyces cerevisiae var. boulardii: In vivo and in silico protection against arsenic-induced redox and hematologic imbalance
Authors: Moses Blessing Thomas; Muankang Junior Tegha Kum; Orhonigbe Innocent; Ozougwu Vincent; Ogara Amaechi; Ugwuene Francis; Agwu Linus, Uhuo Emmanuel; Achi Ngozi; Onoyima Samson; Onoja Remiguis; Ike Mmesoma; and Parker Elijah Joshua. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):126. doi: https://dx.doi.org/10.31183/imcp.2026.00126
4- Investigation of heavy and trace metals contamination in palm wine and locally brewed alcohol from the Ashanti Region of Ghana
Authors: Moses Atosiko Agbala; Joseph Kwasi Adu; and John Nii Adotey Addotey. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):127. doi: https://dx.doi.org/10.31183/imcp.2026.00127
5- Prevalence of asymptomatic carriage of plasmodium falciparum among blood donors at the Biyem-Assi District Hospital in Yaounde, Cameroon
Authors: Jaures Arnaud Noumedem Kenfack; Doriane Esther Djeussi; Cedric Yamssi; Cunegonde Kouogoue Fobasso; Jemimah Sandra Tientcheu Noutong; Abdel Azizi Mounvera; and Christelle Nadia Noumedem Anangmo. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):129. doi: https://dx.doi.org/10.31183/imcp.2026.00129
6- Antidiabetic and antioxidant potential of powder blend of Vigna subterranea, Curcuma longa, and Piper nigrum in streptozotocin-induced rats
Authors: Clautilde Teugwa Mofor; Efraїm Allah-Hissem; Denis Zofou; Florian Amel Tekou; and Jean Paul Dzoyem. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):130. doi: https://dx.doi.org/10.31183/imcp.2026.00130
7- Synergistic antibacterial activity of Erigeron floribundus extracts combined with erythromycin against multidrug-resistant bacteria
Authors: Vincent Ngouana; Mado Solange Ngo Yane; Patrick Valere Tsouh Fokou; Germaine Matsuete Takongmo; Boniface Pone Kamdem; Jean Polidor Nguetsa Demafo; Prisca Laure Nobosse Pewoupa; and Jean-De-Dieu Tamokou. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):131. doi: https://dx.doi.org/10.31183/imcp.2026.00131
8- Assessment of in vivo acute, subacute toxicity, in vitro anti-plasmodial activity, and UPLC-ESI-QToF-MS/MS prediction of Annickia affinis (Exell) Versteegh & Sosef (Annonaceae) roots extract
Authors: Jean Emmanuel Mbosso Teinkela; Jaures Arnaud Noumedem Kenfack; Philippe Belle Ebanda Kedi; Elvira Tachie Mekjele; Thierry Fokou Nzodjou; Noella Molisa Efange; Lawrence Ayong; Else Carole Eboumbou Moukoko; Giselle Marie Marguerite Etamè Loe; and Simone Veronique Fannang. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):132. doi: https://dx.doi.org/10.31183/imcp.2026.00132
9- Evaluation of anti-staphylococcal activity and acute toxicity of hexane extracts of Macaranga occidentalis (Mull. Arg.) Mull. Arg (Euphobiaceae)
Authors: Prosper E. K. Lele; Soreille R. Y. Sofeu; Aimé G. Fankam; Jason B. T. Kuete; Remi R. Nsatar; and Victor Kuete. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):133. doi: https://dx.doi.org/10.31183/imcp.2026.00133
10- Acute and subchronic toxicity of the aqueous extract of Bauhinia thonningii (Caesalpiniaceae) Schum pods
Authors: Rick P.T. Bitchebe; Moïse L. Nchouwet; Sylviane L.K. Poualeu; Liliane M.T. Tchoumba; Marius T. K. Wego; Rostand C.D. Douho; and Sylvie L. N. Wansi. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):134. doi: https://dx.doi.org/10.31183/imcp.2026.00134
11- Investigating the ethanolic extract of Desmodium uncinatum as a natural protector in streptozotocin-induced diabetic nephropathy in Wistar rats
Authors: Jordane W. Kamgaing; Sylviane L. K. Poualeu; Moïse L. Nchouwet; Lylie G. M. Atsafack; Rostand C. D. Douho; and Sylvie L. N. Wansi
Investigational Medicinal Chemistry and Pharmacology 2026 9(1):135. doi: https://dx.doi.org/10.31183/imcp.2026.00135
12- Nanoemulsions of Canarium schweinfurthii sap and Dacryodes edulis kernel essential oils: Chemical profile and in vitro efficacy against diarrheagenic bacteria
Authors: Jaurès Arnaud Noumedem Kenfack; Vincent Ngouana; Doriane E. Djeussi; Joel Nanda Kamassop; and Pierre Michel Jazet Dongmo. Investigational Medicinal Chemistry and Pharmacology 2026 9(1):136. doi: https://dx.doi.org/10.31183/imcp.2026.00136
Cardioprotective effects of hydroalcoholic extract from Cinnamomum zeylanicum stem bark against isoproterenol-induced myocardial infarction in rats
Abstract
Background: The pharmacological properties of Cinnamomum zeylanicum have been predominantly explored in the context of cardiovascular diseases. Given its well-established anti-inflammatory and antioxidant properties, this study aimed to evaluate the cardioprotective potential of the hydroalcoholic extract of Cinnamomum zeylanicum barks (HECZ) against isoproterenol (ISO) induced cardiotoxicity.
Methods: Rats were pre-treated with HECZ (200 - 400 mg/kg, p.o.) or 100 mg/kg of vitami...
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Chemical profiling, molecular docking, and ADMET evaluation of Bougainvillea formosa stem and root barks essential oils
Abstract
Background: Essential oils have been recognized for their pharmaceutical applications as natural antioxidants. A combination of experimental and theoretical analyses was conducted on Bougainvillea formosa (B. formosa) stem and root barks essential oils.
Methods: The essential oils obtained through hydro-distillation were identified and quantified using gas chromatography–mass spectrometry (GC-MS) and were found to exhibit different compositions. The antioxidant capacity of the es...
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